Assessment of Plasminogen Activator Inhibitor- 1(PAI1) In Children with hemophilia A.
Abd-Elhalim, S., Hussien, A., Abdel Rahman, A., Morgan, D. (2025). Assessment of Plasminogen Activator Inhibitor- 1(PAI1) In Children with hemophilia A.. EKB Journal Management System, 6(4), 62-73. doi: 10.21608/ejmr.2025.384399.1830
Sahar Salah Abd-Elhalim; Amany Korany Hussien; Aya Ahmad Abdel Rahman; Dalia Saber Morgan. "Assessment of Plasminogen Activator Inhibitor- 1(PAI1) In Children with hemophilia A.". EKB Journal Management System, 6, 4, 2025, 62-73. doi: 10.21608/ejmr.2025.384399.1830
Abd-Elhalim, S., Hussien, A., Abdel Rahman, A., Morgan, D. (2025). 'Assessment of Plasminogen Activator Inhibitor- 1(PAI1) In Children with hemophilia A.', EKB Journal Management System, 6(4), pp. 62-73. doi: 10.21608/ejmr.2025.384399.1830
Abd-Elhalim, S., Hussien, A., Abdel Rahman, A., Morgan, D. Assessment of Plasminogen Activator Inhibitor- 1(PAI1) In Children with hemophilia A.. EKB Journal Management System, 2025; 6(4): 62-73. doi: 10.21608/ejmr.2025.384399.1830

Assessment of Plasminogen Activator Inhibitor- 1(PAI1) In Children with hemophilia A.

Egyptian Journal of Medical Research
Volume 6, Issue 4, October 2025, Pages 62-73    PDF (522.25 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2025.384399.1830
Authors
Sahar Salah Abd-Elhalim1; Amany Korany Hussien* 2; Aya Ahmad Abdel Rahman3; Dalia Saber Morgan1
1Pediatrics department, Faculty of Medicine, Beni-Suef University, Egypt.
2Pediatrics department Health, Insurance hospital, Benisuef, Egypt.
3Clinical Pathology department, Faculty of Medicine, Beni-Suef University, Egypt
Abstract
Deficiency of coagulation factor VIII causes the x-linked recessive condition known as hemophilia A.  This investigation aims to establish a correlation among PAI-1 and the severity of bleeding in hemophiliac children. Twenty-five children with hemophilia A and twenty-five typically developing children served as subjects in a case control study.  After carefully examining the data, we found that the PAI-1 Level was significantly lower in the cases group contrasted with the control group. Furthermore, a negative connection (r=-0.616, p<0.001) was found among the PAI-1 Level as well as the ISTH-BAT score, determined by the International Society of Thrombosis as well as Hemostasis-Bleeding Assessment Tool.  Because PAI-1 level is a great predictor of hemophilia, we concluded that it was lower in haemophilia A patients in contrast to healthy controls.
Keywords
HaemophiliaA; PAI-1; ISTH-BAT
References
 

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