Misoprostol Alone Versus Misoprostol Preceded by Letrozole for Time Needed for Induction of Miscarriage in Cases of Missed Miscarriage | ||
| Evidence Based Women's Health Journal | ||
| Volume 15, Issue 15, January 2025, Pages 1-5 PDF (317.81 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ebwhj.2024.344777.1400 | ||
| Authors | ||
| ibrahim badr* 1; Nabil Essawy2; Hany Saad2; Maha Mosaad2; Dalia Farouk2 | ||
| 1Department of Obstetrics & Gynecology , Cairo University's faculty of medicine | ||
| 2Department of Obstetrics and Gynecology , Faculty of Medicine, Cairo University , Egypt. | ||
| Abstract | ||
| Objective: The aim is to assess the effect of use of letrozole prior to misoprostol versus use of misoprostol only on termination time during induction of medical evacuation in cases of missed abortion. Methods: This is a randomized controlled trial including a total of 70 pregnant women diagnosed with first trimesteric missed miscarriage , divided into two groups. First group was given letrozole before start of induction with Misoprostol, second group was given misoprostol only. The rate of successful medical abortion without the need for surgical intervention was calculated as a primary outcome, with secondary outcomes including need of surgical intervention, and time needed for complete medical abortion. Results: The induction to complete abortion interval was significantly different between the two groups (6.77±2.21 in letrozole group vs. 11.72±3.18 in misoprostol group, P<0.05). Complete abortion was significantly higher in the letrozole group (71.4%) than in the misoprostol group (48.5% ), P value 0.031. Conclusion: Letrozole when added to misoprostol can increase the rate of successful medical abortion. | ||
| Keywords | ||
| Induction of miscarriage; letrozole; misoprostol; missed miscarriage | ||
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