Beneficial Therapeutic Impact of Berberine and Dopenzil on Neurotoxicity in Rats | ||
| Delta Journal of Science | ||
| Articles in Press, Accepted Manuscript, Available Online from 30 October 2025 | ||
| Document Type: Research and Reference | ||
| DOI: 10.21608/djs.2025.432707.1234 | ||
| Authors | ||
| Eman M. Mostafa1; Doha M Beltagy2; tarek mohamed ali3; Batoul Mohamed Izzularab* 4 | ||
| 1Demonstrator of Biochemistry- Biochemistry Department- Faculty of Science - Damanhour University | ||
| 2Department of Biochemistry ,Faculty of Science, Damanhour University, Egypt | ||
| 3professor of biochemistry , chemistry department , tanta university , tanta | ||
| 4Biochemistry Department, Faculty of Science, Damanhour University | ||
| Abstract | ||
| Alzheimer's disease (AD) is a neurological ailment is marked by cognitive impairment, oxidative stress, and damage to neurons. Berberine chloride (BBR) is an antioxidant supplement that can help with oxidative stress that comes from brain injury. This study sought to investigate the therapeutic potential of BBR. It also aimed to identify any synergistic effects when paired with donepezil treatment on cerebral injury in rats. We set up seven experimental groups: control group that got saline (GI), control group that got berberine (GII), control group that got donepezil (GIII), AlCl₃/D-galactose-induced AD group (GIV), AD group that got berberine (GV), AD group that got donepezil (GVI), and AD group that got both berberine and donepezil (GVII). We looked at biochemical markers such catalase activity, levels of noradrenalin, liver and kidney function, lipid profile, and calcium levels. A histopathological study was conducted to assess neuronal integrity. The AD model group showed a lot of oxidative stress, low levels of noradrenalin and serious damage to neurons in the hippocampus. Berberine or donepezil alone partially corrected these changes, making the antioxidant defense, neurotransmitter balance, and tissue morphology better. The combination therapy notably yielded the most significant reinstating biochemical and morphological change in hippocampus beyond the effects of either treatment alone. In conclusion, BBR exhibited significant neuroprotective and metabolic advantages, and its conjunction with donepezil had synergistic effects against Alzheimer's disease-like pathology. These findings indicate that berberine presenting a viable approach for the management of Alzheimer’s disease. Further studies are recommended to explore its clinical translation. | ||
| Keywords | ||
| Alzheimer'; s disease; Berberine chloride; noradrenaline; Donepezil; oxidative stress | ||
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