The Role of MicroRNA-21 in Psoriasis Vulgaris | ||
| Benha Journal of Applied Sciences | ||
| Volume 10, Issue 5, May 2025, Pages 89-94 PDF (366.83 K) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/bjas.2025.357436.1581 | ||
| Authors | ||
| Ahmed Abd El Whab Saleh1; Seham Gouda Ameen2; Aliaa Mohamed3; Karem Taha Ibrahim4; YOSIF AYOOB MUSA* 5 | ||
| 1Assistant Professor of Dermatology, Venereology and Andrology Faculty of Medicine -Benha University | ||
| 2Assistant Professor of Clinical and Chemical Pathology Faculty of Medicine, Benha University | ||
| 3Lecturer of Dermatology,Venerology and Andrology Faculty of Medicine - Benha University | ||
| 4Lecturer of Dermatology,Venereology and Andrology Faculty of Medicine - Benha University | ||
| 5Department of Dermatology, Venereology and Andrology Faculty of Medicine -Benha University | ||
| Abstract | ||
| Background: Psoriasis vulgaris is an immune-mediated skin disorder driven by miR-21–mediated survival of autoreactive T cells, pro-inflammatory STAT3 signaling, and keratinocyte hyperproliferation through suppression of regulatory genes such as PDCD4 and PTEN. MicroRNA-21 (miR-21), a 22-nucleotide non-coding RNA, is significantly overexpressed in psoriatic skin compared to healthy controls. Objective: To evaluate the role of miR-21 in the diagnosis, prognosis, and therapeutic monitoring of psoriasis vulgaris. Methods: A literature search of Medline databases (PubMed and Medscape) was conducted up to 2023. Studies were included if they were peer-reviewed, English-language articles that assessed miR-21 expression in lesional skin or blood samples (serum or plasma) of psoriasis vulgaris patients. Study Selection: Each study was independently reviewed. Inclusion criteria required relevant assessment of miR-21 expression and clinical correlation in psoriasis vulgaris. Studies were excluded if they lacked control groups, methodological clarity, or outcome relevance. Data Extraction and Quality Assessment: Data were independently extracted using a structured form. Studies were assessed for quality based on availability of controls, evaluation metrics, completeness of reporting, and ethical approval. Results and Conclusion: miR-21 is consistently overexpressed in psoriatic patients and correlates positively with PASI scores, supporting its role in disease severity assessment. Its modulation following treatment suggests potential as a diagnostic and prognostic biomarker and a future therapeutic target. | ||
| Keywords | ||
| Pemphigoid skin condition; microRNA-21; PASI Score | ||
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