EFFECT OF LONG-TERM ADMINISTRATION OF MONOSODIUM GLUTAMATE ON THE HISTOLOGICAL STRUCTURE OF THE THYROID GLAND IN ADULT MALE ALBINO RATS | ||
| Assiut Veterinary Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 30 October 2025 PDF (714.54 K) | ||
| Document Type: Research article | ||
| DOI: 10.21608/avmj.2025.381870.1690 | ||
| Authors | ||
| ALI A. TALA'A1; Y. Y AL-SEADY2; AMER M. HUSSIN3; OMAR HAMMOODI* 4; NAJEM OBAID5; MUNTADHER SALMAN ASHOUR6 | ||
| 1Anatomy and Histology Department, College of Veterinary Medicine, University of Fallujah, Iraq. | ||
| 2Department of applied biological science, College of Biotechnology, Al-Nahrain University,Jadriya, Baghdad, Iraq. | ||
| 3Department Of Health and Medical Laboratory Techniques, Technical College Of Health and Medicine, Imam Ja'afar Al-Sadiq University, Baghdad, Iraq. | ||
| 4Department of Surgery and Obstetrics, College of Veterinary Medicine, University of Fallujah, Iraq. | ||
| 5Department of Basic Sciences, College of Dentistry, Mustansiriyah University, Iraq. | ||
| 6Department of Biology, College of Education for Pure Sciences Ibn AL- Haitham, University of Baghdad, Baghdad, Iraq. | ||
| Abstract | ||
| This study focuses on the effect of long-term intake of monosodium glutamate (MSG) food additives on the histological picture of the thyroid gland in adult male albino rats. Forty adult male rats were divided into four groups. Control groups (C1 and C2) were orally administered only distilled water for 30 and 75 days, respectively. The treatment groups (G1 and G2) were orally administered 15 mg/body weight MSG for 30 and 75 days, respectively. At the end of the experiment, all specimens were sacrificed, and samples were fixed in 10% neutral buffered formalin (NBF). Hematoxylin-eosin (H&E) stain was used for staining. Tissues were examined under the light microscope. As the treatment time of the experiment progressed, the results indicated the presence of hyperthyroidism, characterized by significant hypertrophy of thyroid follicles and hyperplasia of thyroid follicular cells, alongside a low height of the follicular epithelium. This epithelium ranged mostly between high squamous and low cuboidal. High cuboidal to columnar follicular cells were not observed. Some follicles were engorged with thin, homogenous colloids, others contained thick, coagulated colloids. Long-term treatment groups exhibited the fusion of smaller or medium-sized follicles, creating larger ones. It was recorded that the prolonged intake of MSG induces a state of exaggerated functional overload on the thyroid gland. Continuous pressure on the free surface of the follicular cells may lead to increased mitotic activity and could potentially. Despite their limited activity, squamous cells may exhibit the highest activity when their numbers increase on account of their limited function. | ||
| Keywords | ||
| Food additive; Hyperthyroidism; Monosodium glutamate; Thyroid gland | ||
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