Histopathological Assessment of the Safety and Efficiency of Hyaluronic Acid Filler Augmentation in Rats’ Labial Dermal Matrix (Histological, Histochemical & Immunohistochemical Study) | ||
| Ain Shams Dental Journal | ||
| Volume 38, Issue 2, June 2025, Pages 475-487 PDF (1.87 M) | ||
| Document Type: Original articles | ||
| DOI: 10.21608/asdj.2025.341418.1694 | ||
| Authors | ||
| Rania Ahmed Awwad* 1; Nesreen Nabil Abdelsalam2 | ||
| 1Oral biology Department, Faculty of dentistry, Ain Shams University, Cairo, Egypt. | ||
| 2Oral biology department, Mansoura University & Egyptian Russian Uni. Cairo, Egypt | ||
| Abstract | ||
| Aim: to assess the safety and efficacy of HA in restoring the labial volume and shape while maintaining its structural integrity. Materials and methods: 30 rats were equally divided into two main groups; Group I (Control): Included fifteen adult rats injected subcutaneously with saline. Group ІІ: experimental groups, included fifteen rats whose lower lip mucosae were injected with 0.02 ml HA filler. Each of the control and experimental groups were equally subdivided into three subgroups, Subgroup A: sacrificed 7 days after injection. Subgroup B: sacrificed 14 days after injection. Subgroup C: sacrificed 28 days after injection. Lip specimens were processed for routine H&E examination, histochemical examination using Alcian blue & Picro Sirious Red stain, as well as Immunohistochemical assessment using anti-cox2 . Results: experimental groups displayed more vacuolated epithelial cells, more inflammatory cell infiltration, more cox-2 positive cells and more collagen hyalinization within the connective tissue . Conclusion: HA filler induced a moderate foreign body reaction whose intensity increased with time. | ||
| Keywords | ||
| Hyaluronic acid filler; labial demal matrix; foreign body reaction | ||
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