Stem Cells-Derived Exosomes Versus Injectable-Platelet Rich Fibrin effect on Irradiated Submandibular Salivary Glands | ||
| Ain Shams Dental Journal | ||
| Volume 38, Issue 2, June 2025, Pages 512-527 PDF (1.43 M) | ||
| Document Type: Original articles | ||
| DOI: 10.21608/asdj.2025.343693.1717 | ||
| Authors | ||
| Basant Abdelmonaem Mahmoud* 1; Marwa M Abd El-Hameed2; Nuha Abdul-Fattah Baraka3 | ||
| 1Oral Biology department faculty of dentistry Ain shams university | ||
| 2Oral Biology department, faculty of dentistry, Ain shams university | ||
| 3Oral Biology department , faculty of dentistry , Ain shams university | ||
| Abstract | ||
| Aim: This study aimed to compare the ameliorative potentials of Injectable-Platelet Rich Fibrin (I-PRF) and Bone marrow mesenchymal stem cells (BM-MSCs) derived exosomes on irradiated rat submandibular salivary glands (SMGs). Materials and Methods: Forty-nine male albino rats had been divided into 4 main groups (12 rats each) and one rat had been used as doner. Group I served as –ve control while Group II had been exposed to gamma irradiation (single dose of 6 Gy) and the other two groups were injected 24 h post-radiation with a single dose of I-PRF (Group III), exosomes (Group IV). SMG regeneration was assessed in terms of histological changes, ultra-structural changes and TGF- β1 gene expression. Results: The results showed that compared to the irradiated group all treated groups showed successful regeneration. Our results prove that using I-PRF and Exosomes could be promising in decreasing irradiation side effects on SMG. Conclusion: BM-MSCs derived exosomes and IPRF had a role in regeneration of irradiated SMG. Our results demonstrated that using IPRF had ameliorative effect in regeneration of irradiated SMG but for a short-term duration unlike exosomes that mediate a better regenerative effect on long term duration. | ||
| Keywords | ||
| Transmission electron microscope; regeneration; transforming growth factor beta | ||
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