Research Methods in Antidiabetic Studies: Implications of Sri Lankan Herbs | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Articles in Press, Accepted Manuscript, Available Online from 31 October 2025 | ||
| Document Type: Review Article | ||
| DOI: 10.21608/bfsa.2025.425171.2753 | ||
| Authors | ||
| Gayani Imanthika Dias1; Mohamed Shafras* 1; Monica Gulati2; Bhupinder Kapoor2; Avijit Majumdar3 | ||
| 1Department of Physical Sciences and Technology, Faculty of Applied Sciences, Sabaragamuwa University of Sri Lanka, Belihuloya, 70140, Sri Lanka | ||
| 2School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T. Road (NH-1), Punjab, Phagwara, 144411, India | ||
| 3Noida Institute of Engineering and Technology [Pharmacy Institute], 19 Knowledge Park-2G.B Nagar, U.P, Greater Noida, 201 306, India | ||
| Abstract | ||
| Diabetes is an escalating global health concern, and Sri Lanka records one of the highest prevalence rates in Asia. Increasing scientific interest has focused on the antidiabetic potential of Sri Lankan medicinal plants, supported by the country’s rich biodiversity and traditional healing practices such as Ayurveda. This review examines the research methodologies used to evaluate the antidiabetic activity of Sri Lankan herbs, based on literature retrieved from Web of Science, PubMed, and Google Scholar. Studies on approximately 50 plant species that are extensively used in Ayurvedic practice are discussed, highlighting in vitro, ex vivo, in vivo, clinical, and in silico approaches such as enzyme inhibition and glucose uptake assays. Although numerous studies demonstrate the antidiabetic effects of aqueous and organic extracts, the specific bioactive compounds responsible for these activities remain largely unidentified. This review emphasizes methodological advances, current research gaps, and Sri Lanka’s growing contribution to the global search for novel plant-derived antidiabetic agents. | ||
| Keywords | ||
| Diabetes mellitus; Antidiabetic research; Research methodologies; Sri Lankan herbs; Herbal medicine | ||
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