Microbial Siderophores: Detection, Classification, Importance in Bacterial Pathogenesis and Applications in Medicine | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Articles in Press, Accepted Manuscript, Available Online from 31 October 2025 | ||
| Document Type: Review Article | ||
| DOI: 10.21608/bfsa.2025.429413.2778 | ||
| Authors | ||
| Esraa Adel* 1; Farah H. Omer1; Enas Yaseen Shehab2; Essra Ghanim Alsammak3 | ||
| 1College of Pharmacy, University of Mosul, Mosul, Iraq | ||
| 2College of Dentistry, University of Mosul, Mosul, Iraq, | ||
| 3College of Science, University of Mosul, Mosul, Iraq | ||
| Abstract | ||
| Siderophores are low-weight molecules used to chelate the ferric iron produced as an iron deficiency response by microbes to provide this essential metal nutrient to the cells. Siderophores released into their habitat to collect iron and bring it drive into the cell, circumventing abiotic tension caused by heavy metals to reduce biotic tension in the hosts. Iron is a necessary micronutrient to life forms, as microorganisms require at least 10⁻⁶ M of Fe³⁺ for their growth; these microbes readily draw out Fe³⁺ from various environments for their survival. circumventing abiotic stresses caused by toxic heavy metals to lessen biotic tension in the hosts. Iron is an essential micronutrient for forms of life, as microorganisms need at least 10⁻⁶ M of Fe³⁺ for their growth; these microbes, for their survival, they readily draw out Fe³⁺ iron from a variety of environments. This review will discuss the detection, classification, importance of siderophore production in bacterial pathogenesis and the main employment of siderophores in medical science. | ||
| Keywords | ||
| Microbial siderophores; Iron; CAS assay; Cancer; Medicine | ||
|
Statistics Article View: 4 |
||
