The Role of Systemic Inflammatory Indices in Children with Parapneumonic Pleural Effusion | ||
| The Egyptian Journal of Pediatric Allergy and Immunology | ||
| Volume 23, Issue 2, October 2025, Pages 82-88 PDF (353.9 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejpa.2025.368809.1087 | ||
| Authors | ||
| Sally Raafat Ishak* 1; Mona ElGanzoury2; Nesma Mohammed3; Sara Ibrahim Taha4; Yara Taher5; Heba Moustafa Hamza6 | ||
| 1Pediatric Department, Ain Shams University | ||
| 2Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||
| 3Pediatrics Department, Ain Shams University | ||
| 4Department of Clinical Pathology/ Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. | ||
| 5Pediatrics Department, Faculty of Medicine, Ain Shams University, Egypt | ||
| 6Pediatrics, Faculty of Medicine , Ain Shams University, Egypt | ||
| Abstract | ||
| Background: Parapneumonic effusion (PPE) is a common complication of community-acquired pneumonia (CAP) in children, classified as complicated (CPPE) or uncomplicated (UPPE). Differentiating between these types aids in appropriate management and improves outcomes. This study evaluates the diagnostic utility of systemic inflammatory indices in distinguishing CPPE from UPPE in pediatric patients. Methods: A cross-sectional study of 90 children with PPE categorized into CPPE and UPPE groups based on laboratory and imaging findings. Systemic immune inflammatory index (SII), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), derived neutrophil-to-lymphocyte ratio (dNLR), lymphocyte-monocyte ratio (LMR), and C-reactive protein/albumin (CRP/Alb) ratio were calculated. Results: The CRP/Alb ratio was significantly higher in the CPPE group (p = 0.013). ROC analysis identified a CRP/Alb ratio >113.46 as a predictor of CPPE with 85.71% specificity and 44.12% sensitivity. Multivariate regression analysis identified parainfluenza virus infection and the CRP/Alb ratio as significant predictors of CPPE (OR = 17.12, p = 0.009). Conclusions: Among the inflammatory indices analyzed, the CRP/Alb ratio was the most reliable marker for differentiating CPPE from UPPE. | ||
| Keywords | ||
| Systemic Inflammatory Indices; Parapneumonic Pleural Effusion; CRP/Albumin Ratio | ||
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