Value of three-dimensional saline infusion sono-hysterography (3-D SIS) in the diagnosis of endometrial and intracavitary pathology in perimenopausal women presenting with abnormal uterine bleeding. | ||
| Evidence Based Women's Health Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 November 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ebwhj.2025.437884.1527 | ||
| Authors | ||
| Nihal Mostafa El-Demiry* 1; Sherif Elsirgany2; Shaimaa Yassen1; Hisham Kandil1; Nadia Helmy3 | ||
| 1Department of Obstetrics and Gynecology, Kasr Al-Ainy Hospital, Cairo University, Cairo, Egypt. | ||
| 2Reproductive Health Research Department, National Research Centre, Cairo, Egypt. | ||
| 3Department Of Obstetrics and Gynecology, Kasr Al-Ainy Hospital, Cairo University, Cairo, Egypt. | ||
| Abstract | ||
| Objective: Compare between 2-D transvaginal sonography (TVS) & 3-D saline infusion sono hysterography (SIS) in the detection of endometrial and intracavitary pathologies in perimenopausal patients presenting with abnormal uterine bleeding. Material and Method: Prospective observational study was performed including 146 perimenopausal cases experiencing abnormal uterine bleeding at gynaecology clinic, obstetrics and gynaecology department, Kasr Al-Ainy Hospital, Cairo University, over a duration of six months. All cases underwent 2-D TVS & 3-D SIS of the uterus to identify any endometrial and intracavitary pathologies. Results: As a diagnostic tool for endometrial polyps’ detection; sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of the 3-D SIS were 86.3%, 81.9%, 77.9%, 88.1% and 84.6% respectively and for submucous fibroid detection were 74.1%, 89.7%, 80.7%, 88.3% and 77.4% respectively compared to the diagnostic accuracy of 2-D TVS which revealed 70.5% sensitivity, 74.8% specificity, 65.9% PPV, 84.8% NPV and 66.4% accuracy in detecting endometrial polyps & 73.9% sensitivity, 89% specificity, 77.8% PPV, 82.1% NPV and 75.3% accuracy in detection of submucous myoma. Conclusion: In perimenopausal patients, 3-D SIS is considered a non-invasive procedure that provides an additional benefit in detecting the cause of abnormal uterine bleeding, showing high correlation with the histopathological results. | ||
| Keywords | ||
| Perimenopausal bleeding; three-dimensional saline infusion sono-hysterography (3-D SIS); abnormal uterine bleeding | ||
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