Antimicrobial and therapeutic potential of Moringa oleifera nano emulsion in treating Cryptosporidium parvum Infection | ||
| Microbes and Infectious Diseases | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 November 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mid.2025.428964.3280 | ||
| Authors | ||
| Roqayah Saleh Al-Habeeb* ; Mina A. A. Almayouf | ||
| Department of Biology, College of Science, Qassim University, Buraydah, Saudi Arabia. | ||
| Abstract | ||
| Background: The "tree of life" or "miracle tree," Moringa oleifera, is regarded as a significant herbal plant because of its numerous therapeutic and non-therapeutic uses. Objective: This research aims to prepare and evaluate a novel Moringa oleifera nano-emulsion for analysis of the pharmacological activities against pathogenic microbes and Cryptosporidium parvum infection in mice, compared to the patent drug, Nitazoxanide (NTZ). Methods: The present study deals with the gas chromatography–mass spectrometry (GC–MS) analysis of M. oleifera oil seeds for preparation nano emulsion. Antimicrobial activity was evaluated using the well diffusion method. Adult male mice were divided into five groups for Cryptosporidium infection induced orally with the oocysts (1×103 oocysts/mouse). Results: These findings suggest that Moringa oleifera contains high fatty acids and the nano-emulsion was successfully prepared. Crude moringa oil showed strong efficacy against bacteria and fungi. The marked improvement in oocysts shedding was recorded in both Cryptosporidium parvum-infected and M. oleifera-treated groups (G3 & G4) with significant efficacy (P<0.05). Conclusion: Treatment therapy using Moringa oleifera nano-emulsion is a novel potential natural product for reducing microbial growth as well as the number of Cryptosporidium parvum oocysts shedding and improving e pathological changes in infected mice | ||
| Keywords | ||
| Moringa oleifera; Cryptosporidiosis; Antimicrobial activity; Nano emulsion; Parasitology | ||
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