Electrospun Poly-Lactic Acid Nanofibers for Dual Drug Delivery in Regenerative endodontics: Ciprofloxacin and Metronidazole Loading and Characterization | ||
| Ain Shams Dental Journal | ||
| Volume 38, Issue 2, June 2025, Pages 679-692 PDF (1.47 M) | ||
| Document Type: Original articles | ||
| DOI: 10.21608/asdj.2025.342662.1709 | ||
| Authors | ||
| Mai saleh ghoneim* 1; Abeer Hashem Mahran2; Ashraf M. Abu-Seida3; engy kataia4; Radwa mahrous Abd El-al5 | ||
| 1Researcher assistant ,Endodontic Department , national research center. Cairo ,Egypt | ||
| 2Faculty of Oral and Dental Medicine, Head of endodontic department Ain Shams University | ||
| 3Dept. of Surgery, Anesthesiology & Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt Faculty of Dentistry, Galala University, New Galala city, Suez, Egypt | ||
| 4Professor, Department of Endodontics, Faculty of Dentistry, The British University in Egypt (BUE), El Sherouk City, Egypt. Professor, Restorative and Dental Materials Department, National Research Centre, Giza, Egypt. | ||
| 5Department: Pharmaceutics and Drug Manufacturing. faulty of pharmacy, Modern Technology and Information University (MTI). | ||
| Abstract | ||
| Aim: This study presents the synthesis, material characterization, and evaluation of the antimicrobial activity of antibiotic-loaded scaffolds. Materials and methods: Metronidazole (MID) or Ciprofloxacin (CIP) was incorporated into a polylactic acid (PLA) polymer solution at a concentration of 25 wt.% and then processed into Fibers. Neat PLA nanofibers were used as controls. Characterization techniques, including scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), degradation tests, and drug release assessments, were employed. The antimicrobial properties were tested against Porphyromonasgingivalis (Pg) and Enterococcus faecalis (Ef). Results: SEM imaging showed Fibers with submicron diameters, and FTIR confirmed the successful incorporation of the antibiotics. Data analysis demonstrated a gradual and sustained release of the drugs from the scaffolds over 48 hours. Antimicrobial activity was confirmed via agar diffusion assays, showing efficacy against the tested bacteria. Conclusion: Antibiotic-loaded electrospun PLA scaffolds could serve as biologically safe antimicrobial drug delivery systems for use in regenerative endodontics. | ||
| Keywords | ||
| Electrospinning; PLA Nanofibers-scaffold; Drug delivery; Regenerative Endodontic Procedure | ||
|
Statistics Article View: 5 PDF Download: 2 |
||
