Potential Role of Gum Arabic on Calcium Homeostasis in Adenine-Induced Chronic Renal Failure in Rats | ||
| Mansoura Journal of Biology | ||
| Volume 42, Issue 1, March 2019, Pages 23-34 PDF (918.08 K) | ||
| Document Type: Research Article | ||
| DOI: 10.21608/mjb.2019.463323 | ||
| Authors | ||
| EL-Sayed M. El-Habibi* ; Ayman E. Salem; Mostafa M. Dalal | ||
| Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt. | ||
| Abstract | ||
| The present study aimed to investigate the effect of gum Arabic (GA) on calcium (Ca) homeostasis in adenine (AD)-induced chronic renal failure (CRF) in male rats. Twenty four adult male rats were divided into four groups (six rats each): Control (C) group without treatment, GA (15%w/v) in drinking water treated group, AD (300 mg/kg/day) intragastric treated group, AD and GA treated group. All treatments continued for 4 weeks. The results showed that AD treatment caused renal disorders, resembling CRF represented by significant increase in serum creatinine, BUN and uric acid levels associated with increase in urine volume, kidney weights, the levels of microprotein and NAG activity in urine. Also, creatinine clearance and body weight were significantly decreased. Renal oxidative stress marker Malondialdehyde (MDA) was increased with significant reduction in the activities of superoxide dismutase (SOD), catalase (CAT), the level of reduced glutathione (GSH) and total antioxidant capacity (TAC). AD treatment caused hormonal disorders, elevated levels of parathormone (PTH) and calcitonin (CT), but calcitriol levels decreased. In addition, disturbances in serum and urine mineral levels (Ca, P, Na and K) were observed associated with histopathological changes in renal sections. Moreover, GA administration improved kidney function and calcium (Ca) homeostasis as it keeps the levels of the measured parameters tended to normal level and prevented the oxidative stress induced by AD. | ||
| Keywords | ||
| chronic renal failure; calcium homeostasis; adenine; gum Arabic; electrolytes | ||
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