Chemical composition and biological activity of extracts and essential oils of Ziziphora capitata L and Ziziphora tenuior L: A review | ||
| Egyptian Journal of Chemistry | ||
| Articles in Press, Accepted Manuscript, Available Online from 02 November 2025 | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/ejchem.2025.381947.11714 | ||
| Authors | ||
| YOUSSIF MAHMOUD YOUSSIF* 1; gameel Ahmed Elhagali2; Ahmed Ragab3; Medhat A. Zahran2; Fatma Ali Ahmed4 | ||
| 1Medicinal and Aromatic Plants Department, Desert Research Center, Matariya, Cairo,11753 Egypt | ||
| 2Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, 11884, Egypt | ||
| 3Chemistry DChemistry Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, 11884, Egyptepartment-Faculty of Science - Al-Azhar University Cairo,Chemistry Department, Faculty of Science, Galala University, Galala | ||
| 4Medicinal and Aromatic Plant Department, Desert Research Center, Cairo, Egypt. | ||
| Abstract | ||
| Ziziphora capitata L. and Ziziphora tenuior L., members of the Lamiaceae family are versatile plants known for their culinary and medicinal properties. This comprehensive review focuses on medicinal potential through an analysis of phytoconstituents, biological activities, and traditional medicinal uses. A literature review revealed that the extracts of Z. capitata L. and Z. tenuior L. contain significant flavonoid and phenolic content. Metabolite profiling identified flavonoids, phenolic acids, anthocyanins, coumarins, and other bioactive compounds, and essential oils (EOs) contain pulegone as a major constituent. Studies have shown that these plants have a remarkable ability to scavenge free radicals, which contributes to the reduction of oxidative stress in cells. Advanced techniques such as UPLC-QTOF-MS/MS, GC-FID, and GC–MS have been used to identify the compounds responsible for antioxidant, antibacterial, and cytotoxic activities, leading to the discovery of a wide range of flavonoids and phenolic acids. The cytotoxic activities of Z. capitata against HepG-2, MCF-7, HCT-116, A549, and PC3 cell lines were evaluated, indicating potential anticancer properties, in addition to antibacterial and antioxidant activities against bacterial strains extracts, and essential oil. Overall, this review underscores the medicinal significance of Ziziphora species, particularly their phytoconstituents, antioxidant, antimicrobial, anticancer, and immunostimulatory properties. These findings provide a basis for further investigation and potential development of Ziziphora-based therapeutics and nutraceuticals | ||
| Keywords | ||
| Ziziphora capitata; Ziziphora tenuior; Lamiaceae; Flavonoids; Antimicrobial activity; Antioxidant; Cytotoxic activity | ||
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