A Comprehensive Review on Lepidium sativum as a Promising Green Excipient for Sustainable Pharmaceutical Formulations | ||
| Egyptian Journal of Chemistry | ||
| Articles in Press, Accepted Manuscript, Available Online from 02 November 2025 | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/ejchem.2025.420930.12301 | ||
| Authors | ||
| Enaam Mohamed AbouZeid* 1; Rabab Kamel2; Hamdy Dawaba3; Aya Dawaba4 | ||
| 1Department of Pharmacognosy, Pharmaceutical and Drug Indutsries Research Institute, National Research Centre, Cairo, Egypt | ||
| 2Pharmaceutical technology Department, Pharmaceutical Research and Drug Industries Institute, National Research Centre, Cairo 12622, Egypt | ||
| 3Department of Pharmaceutics and pharmaceutical technology, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt | ||
| 4Department of Pharmaceutics and pharmaceutical technology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt | ||
| Abstract | ||
| The escalating demand for natural, biodegradable, and cost-effective pharmaceutical excipients necessitates the exploration of novel plant-derived materials. Lepidium sativum, commonly known as garden cress, has been traditionally used in various medicinal preparations due to its rich nutritional profile and potential therapeutic properties. This article discusses the feasibility of the use of L. sativum as a pharmaceutical excipient, focusing on its potential applications and advantages over conventional excipients. The botanical characterization of L. sativum is presented together with its phytochemical composition revealing a diverse array of bioactive compounds which have been associated with antioxidant, anti-inflammatory, and antimicrobial activities, suggesting potential benefits in various pharmaceutical formulations. The favourable properties of L. sativum to act as a pharmaceutical agent such as a disintegrant, binder, gelling and mucoadhesive for inclusion in different dosage forms, are also displayed. In conclusion, this article provides evidence that L. sativum can be considered a promising pharmaceutical excipient. Its rich phytochemical composition, favourable physicochemical properties, availability, and compatibility with various active pharmaceutical ingredients make it a potential alternative to conventional and synthetic excipients. Further research is warranted to explore the specific applications and advantages of L. sativum in pharmaceutical formulations. | ||
| Keywords | ||
| Garden cress; seed; mucilage; extraction; formulation; therapeutics; dosage forms | ||
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