MOLECULAR DOCKING OF BERBERINE TO REDUCE OSTEOARTHRITIS INDUCED BY HYDROXYZINE IN MALE RABBITS | ||
| Assiut Veterinary Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 03 November 2025 | ||
| Document Type: Research article | ||
| DOI: 10.21608/avmj.2025.368460.1629 | ||
| Authors | ||
| Areej GH Al-Charak1; Rzaq Shailaan Kaurshead2; Sadiq Abid Al-Mansury3; Adnan M. Jassim* 1; Ali Jasim Muhamed4; Kareem Obayes Handool5 | ||
| 1College of Veterinary Medicine, AL-Qasim green University, Babylon 5013,IRAQ. | ||
| 2Ministry of Higher Education and Scientific Research Al-Mustaqbal University- College Medical and Health Techniques | ||
| 3College of Veterinary Medicine, AL-Qasim green University, Babylon 5013,IRAQ | ||
| 4Department of Anesthesia Techniques, Alzahraa uinversity, Iraq | ||
| 5Ministry of Higher Education and Scientific Research Al-Mustaqbal University- Medical physic | ||
| Abstract | ||
| Berberine (BBR) has been prescribed in the management of various health conditions, and its potential as a powerful natural remedy continues to attract scientific interest for treatment of inflammatory disease .This study involved twenty four male rabbits, which were randomly divided into four equal groups, each consisting of six rabbits. The first group served as the negative control, while the second group was the positive control, in which arthritis was induced using hydroxyzine. The third group included rabbits with induced arthritis that were treated with berberine, and the fourth group consisted of rabbits with induced arthritis that were treated with leflunomide. The molecular study results demonstrated that celecoxib, when compared to berberine and its active components, exhibited a highly comparable binding affinity with the receptor. Additionally, it showed significant efficacy in inhibiting cyclooxygenase-2 (COX-2), contributing to the reduction of joint inflammation and associated pain. These findings suggest its potential as a future natural therapeutic option, which may help minimize the side effects associated with conventional chemical treatments. The study found that berberine effectively reduced rheumatoid factor levels and C-reactive protein, indicating its potential as a therapeutic agent for RA. | ||
| Keywords | ||
| Oxidative stress; Arthritis; cyclooxygenase-2; berberine (BBR) | ||
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