ZFP36 and IL6 expression in Plaque Psoriasis: A clinical and Immunohistochemical Study | ||
| Al-Azhar International Medical Journal | ||
| Volume 2025, Issue 7, July 2025, Pages 103-111 PDF (501.66 K) | ||
| Document Type: Original Article | ||
| DOI: https://doi.org/10.21608/aimj.2025.446644 | ||
| Authors | ||
| Mona A. Kora* 1; Amira Abdelghany2; Mostafa Hammam3; Wafaa Ahmed Shehata3 | ||
| 1Department of Pathology, MD, Faculty of Medicine, Menoufia University, Shebin al-Kom, Menoufia, Egypt | ||
| 2Dermatologist and Andrologist, MBBCh, Menoufia university, Shebin al-Kom, Menoufia, Egypt. | ||
| 3Department of Dermatology and Andrology, MD, Faculty of Medicine, Menoufia University, Shebin al-Kom, Menoufia, Egypt | ||
| Abstract | ||
| Objectives: ZFP36, a key post-transcriptional regulator, and IL-6, a proinflammatory cytokine, play significant roles in psoriasis pathogenesis. Aim: This study will examine their IHC expression in perilesional and lesional psoriatic skin in contrast to controls. Methods: This study included thirty healthy controls and thirty patients with plaque psoriasis. Clinical data was obtained. Histopathological analysis together with ZFP36 and IL-6 IHC technique were performed. Results: ZFP36 was 100% positive in the epidermis of the control group, with an average positive cell percentage of 84.6±12.1, while in the dermis, positivity was 70% with a mean count of 7.28±5.58/10HPF. In psoriatic lesional skin, epidermal ZFP36 positivity was 80% with a reduced mean positive cell percentage (31.4±19.1), while dermal ZFP36 was observed in 73.3% with a mean count of 35.8±29.2/10HPF. A significant decrease in epidermal ZFP36 positivity, percentage, and H-score was observed across the groups (P = 0.04, 0.001, and 0.001, respectively), while dermal ZFP36 was highest in lesional skin (P = 0.001). For IL-6, epidermal expression was highest in the control group (100%, 65.3±30.8 positive cells) and significantly decreased in psoriatic lesional skin (40%, 28.7±27.3, P = 0.001). Dermal IL-6 was negative in controls but increased dramatically in psoriatic lesional and prelesional skin (P = 0.001). There was a negative connection between dermal ZFP36 and epidermal IL6 (P = 0.03). Conclusion: Our findings suggest that ZFP36 downregulation may contribute to chronic inflammation in psoriasis. The inverse correlation between epidermal IL-6 and dermal ZFP36 expression patterns may indicate their differential regulatory mechanisms in psoriasis pathogenesis. | ||
| Keywords | ||
| Plaque psoriasis; ZFP36; IL6; Immunostaining; Target therapy | ||
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