Resveratrol mitigates Valproic Acid-Induced Autistic Features in mice via up-regulation of Nrf2/HO-1 signaling pathway | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Articles in Press, Accepted Manuscript, Available Online from 04 November 2025 PDF (563 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2025.402927.1225 | ||
| Authors | ||
| Karima El-Sayed Ahmed1; Suzan A Khodir* 2; Noha Abd El-aziz3; Shehab H Hassaan4; Amany Elfakhrany5; Noha Rabie Bayomy6; Sabah Mohamed Sharaf7; Walaa A Fadda8; Azza S Khalil9; Rania Salah Mansour10 | ||
| 1Physiology department, faculty of medicine, Suez canal university | ||
| 2Medical physiology department, faculty of Medicine, Menoufia University | ||
| 3Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt | ||
| 4Psychiatry Department, Sulaiman Alrajhi University, AL Bukayriyah, Saudi Arabia Psychiatry Department, Faculty of Medicine, Assiut University, Assiut, Egypt. | ||
| 5Clinical Pharmacology Department, Faculty of medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt. | ||
| 6Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt. | ||
| 7Pathology Department, Faculty of medicine for Girls, Al-Azhar University | ||
| 8Human Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt Department of Anatomy and Histology, College of Medicine, Qassim University, Buraydah, Saudi Arabia | ||
| 9Physiology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo 11884, Egypt | ||
| 10Medical Physiology Department , Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||
| Abstract | ||
| Introduction: A neurodevelopmental disease known as autism spectrum disorder (ASD) is linked to stereotypical behavior and poor social skills. Resveratrol (Res) has been shown to possess anti-inflammatory and antioxidant impacts. Objective: to demonstrate the underlying mechanisms and neuroprotective impact of Res in VPA-induced ASD Material & methods: Thirty male Swiss mice were split into three : control, VPA, and VPA+Res. Following neurobehavioral testing, the rats were sacrificed, and the cerebellar gene expression of Nrf2 and HO-1 was evaluated together with the measurements of MDA, SOD, TNF-α, IL-6, IL-10 and serotonin. GFAP and Caspase-3 cerebellar immunoreactions were performed. Results: While the VPA group's time of central crossing in OFT, percentage of alternation in the T maze test, Cerebellar SOD, Cerebellar IL-10, and Cerebellar gene expression of Nrf2 and HO-1 were dramatically lower than those of the control, the VPA 's number of crossing slots in OFT, rearing frequency in OFT, Cerebellar MDA, Cerebellar TNF-α, and Cerebellar IL-6 were all dramatically higher than those of the control group with impairments in social interaction. Res substantially reduced VPA-induced ASD. Conclusion: In addition to enhancing gliosis and up-regulating the Nrf2/HO-1 signaling pathway, Res also reduced VPA-induced ASD through anti-oxidant, anti-inflammatory and antiapoptotic pathways. | ||
| Keywords | ||
| Autism. Caspase-3; GFAP. HO-1; Nrf2. Resveratrol | ||
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