Dexmedetomidine Efficacy on Oxygenation During One Lung Ventilation in Thoracic Surgeries: A Prospective Randomized Controlled Study | ||
| Al-Azhar International Medical Journal | ||
| Volume 2025, Issue 9, September 2025, Pages 33-37 PDF (460.1 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/aimj.2025.400920.2618 | ||
| Authors | ||
| Amany Hussein Ibraheim Morsy* 1; Ruqaya Mohamed Elsayed1; Fatma Alzahraa Roshdy Elkemary2 | ||
| 1Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt | ||
| 2Department of anesthesiology ,intensive care & pain management,Faculty of Medicine for girls , Al-Azhar University | ||
| Abstract | ||
| Background: An established approach for thoracic procedures, one-lung ventilation (OLV) allows for more room in the thoracic cavity, which is necessary for the surgery. Improved oxygenation and resolution of hypoxemia during OLV are achieved with the use of dexmedetomidine and other methods. Aim: To determine if dexmedetomidine improves oxygenation during OLV and whether it is safe for patients having thoracic surgery. Subjects and methods: From October 2023 to March 2025, 104 participants participated in this prospective, randomized controlled trial. Two groups of patients were created: one that received maintenance with 2% sevoflurane (the S group) and another that received intravenous administration of Dexmedetomidine (0.3μg/kg) over a 10-minute period (the D group). Results: After 15, 30, and 45 minutes of lung isolation, PaO2 was considerably greater in the D group compared to the S group. When comparing the two groups after 15, 30, and 45 minutes of lung isolation, the PaO2/FiO2 ratio was substantially greater in the D group. After 15, 30, and 45 minutes of lung isolation, the PH values of the S Group were significantly lower than those of the D Group. Conclusion: Without affecting hemodynamic stability or postoperative recovery adversely, dexmedetomidine is an efficient and secure adjuvant for optimizing oxygenation during OLV. | ||
| Keywords | ||
| Thoracic Surgery; Dexmedetomidine; Lung ventilation | ||
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