The Relationship between Zearalenone Produced by Fusarium spp and the Incidence of Polycystic Ovary Syndrome in Women | ||
| Egyptian Journal of Medical Microbiology | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 July 2026 PDF (530.4 K) | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2025.433013.1936 | ||
| Authors | ||
| Mohammad I. Khalil* ; Noor M. Sadeq | ||
| Department Environment Sciences, College of Environmental Sciences, University of Mosul, Iraq | ||
| Abstract | ||
| Background: Zearalenone (ZEN) is a mycotoxin that the fungus produces Fusarium spp., which reaches humans through food contaminated with mycotoxins. The purpose of this study is to look into the presence of zearalenone in the serum among females suffering from polycystic ovary syndrome, how it influences the levels of FSH, or follicle-stimulating hormone and estrogen, and how it relates to CYP19 gene polymorphisms. Methodology: This was accomplished by obtaining blood samples from both healthy women and women with polycystic ovarian syndrome and measuring zearalenone, estrogen, and FSH using ELISA. PCR was also employed to examine the CYP19 gene's SNPs utilizing the HSP92ll enzyme. Results: The findings show that the amount of zearalenone in polycystic ovarian syndrome women's serum (4.03 ± 1.65 ng/ml) was greater than the healthy women (0.5 ± 0.1 ng/ml), Additionally, It was noted that samples of women with PCOS had higher levels of estrogen (60.86 ± 18.27 pg/ml) than samples of healthy women (48.82 ± 17.90 pg/ml). In contrast, samples of blood from polycystic ovarian syndrome patients had lower levels of FSH (5.22±1.56 ml.U/ml) than samples from healthy women (7.55±1.73 ml.U/ml). The PCR results using the HSP92ll enzyme indicate the presence of three the genotype AA (homozygosity) AG (heterozygosity) GG (homozygous) The genotypes in women with PCOS indicate that they are GG, AG, AA (38, 43, 19)% compared to healthy women (20, 35, 45)%, respectively, Conclusions: This study indicates the presence of the toxin zearalenone in PCOS-affected women's blood serum. Toxins in the serum contribute to PCOS. | ||
| Keywords | ||
| Fusarium spp; Zearalenone; PCOS; CYP19 | ||
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