Immunological Role of Soluble CD163 and CD248 Biomarkers in Insulin Resistance among Healthy Iraqi Adults | ||
| Egyptian Journal of Medical Microbiology | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 July 2026 PDF (391.72 K) | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2025.437114.1960 | ||
| Authors | ||
| Ayad M. Gaidan* 1; Ban B. Adnan2; Muhammed A.H. Aldabagh3 | ||
| 1Department of Biology, College of Sciences, University of Tikrit, Tikrit, Iraq. | ||
| 2Veterinary Medicine, University of Tikrit, Tikrit, Iraq | ||
| 3Medical Research Unit, College of Medicine, University of Al-Nahrain, Baghdad, Iraq | ||
| Abstract | ||
| Background: Insulin resistance (IR) is a major metabolic disturbance with associations with inflammation and impaired glucose homeostasis. Soluble CD163 and soluble CD248 are stroma- and macrophage-derived molecules that could bridge immune activation and insulin resistance. Objective: The present study was conducted to identify the serum levels of sCD163 and sCD248, and their association with insulin resistance in apparently healthy Iraqi adults. Methodology: A cross-sectional study was undertaken on 98 euglycemic non-diabetic adults (≥45 years). Participants were categorized according to HOMA-IR values (≤3 = insulin-sensitive, >3 = insulin-resistant). Anthropometric and biochemical parameters were measured, and serum concentrations of sCD163 and sCD248 were determined with ELISA kits. Results: Insulin resistance was present in 25 patients (25.5%). Both sCD163 and sCD248 concentrations were higher in IR individuals than in insulin-sensitive individuals (p < 0.05). Both biomarkers were found to be positively correlated with HOMA-IR and fasting insulin, indicating their implication in metabolic inflammation. Conclusion: Elevated serum sCD163 and sCD248 can serve as an early immunological indicator of insulin resistance in apparently healthy individuals. Monitoring them might be helpful in identifying subclinical metabolic risk. | ||
| Keywords | ||
| Insulin resistance; sCD163; sCD248; Iraq; ELISA | ||
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