Therapeutic Effect of Ultrasound Guided Injection of Dextrose 5% versus Corticosteroids in Patients with Carpal Tunnel Syndrome. | ||
| The Medical Journal of Cairo University | ||
| Volume 93, Issue 09, September 2025, Pages 1045-1054 PDF (601.01 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjcu.2025.464219 | ||
| Author | ||
| ABDALLAH E. ABDALLAH, M.Sc.; IBRAHIM A. ELBOGHDADY, M.D. EMAN B. ELMARGHANY, M.D. | ||
| The Department of Rheumatology, Rehabilitation and Physical Medicine, Faculty of Medicine, Mansoura University | ||
| Abstract | ||
| Background: There are several lines for carpal tunnel syn-drome (CTS) management. However, no standard therapy ex-ists. Perineural injection therapy with dextrose 5% (D5W) has the ability to reduce neurogenic inflammation, however there are scarce studies about its efficacy in CTS therapy. Therefore, Aim of Study: This study aimed to compare the effect of ul-trasound-guided injection of D5W with triamcinolone in man-agement of idiopathic mild and moderate CTS. Patients and Methods: 80 patients with mild to moderate CTS were randomized to D5W group where 5cc of D5W was injected (3cc above the median nerve and 2cc below it) and triamcinolone group where a total volume of 2cc was injected below the median nerve. Ultrasound guided injection approach was used in both groups. Patients were followed for 6 months and assessed at 1, 3, and 6 months by Boston Carpal Tunnel Questionnaire (BCTQ), visual analogue scale (VAS), median nerve (cross sectional area (CSA), electrophysiological tests. Results: This prospective clinical trial involved 80 pa-tients with mild and moderate CTS and they were allocated into two equal groups. Under ultrasound-guidance, one group was treated with D5W perineural injection, and the other group was treated with triamcinolone perineural injection. Significant improvement in Boston Carpal Tunnel Questionnaire BCTQ scores, VAS, and median nerve CSA, sensory latency SL, sen-sory conduction velocity) with no significant change in median nerve distal motor latency DML was observed in both groups at 1, 3, and 6 months post-treatment compared to baseline. In addition, no significant intergroup difference was detected as regards the above-mentioned parameters. Conclusion: In patients with mild and moderate CTS, both D5W and triamcinolone injection groups achieved similar im-provement for 6 months in pain, function, median nerve CSA, and sensory conduction tests parameters. This points to the ef-fectiveness of D5W as a therapeutic alternative to corticoster-oids. Further studies are recommended to verify our findings and illustrate D5w long-term effects. | ||
| Keywords | ||
| Carpal tunnel syndrome; Dextrose 5%; Perineu-ral injection; Triamcinolone | ||
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