Evaluation of Some Biochemical Parameters in Iraqi Methamphetamine Addicts | ||
| Journal of Bioscience and Applied Research | ||
| Articles in Press, Corrected Proof, Available Online from 04 November 2025 PDF (1.2 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jbaar.2025.464246 | ||
| Author | ||
| Khalidah Salih Merzah* | ||
| Osol Al-Elm University College, Iraq | ||
| Abstract | ||
| Background: Methamphetamine (METH) is a potent stimulant of the central nervous system and a highly addictive substance. With a severe neurotoxic effect on the central nervous system (CNS), it is a powerful, highly addictive, and frequently abused pharmaceutical medication. The investigation of liver enzymes, like aspartate aminotransferase (AST) and alanine aminotransferase (ALT), is linked to METH addiction, as well as certain elements, such as sodium and calcium, because of their link to elevated neurotransmission brought on by METH addiction. Objective: A study of the impact of METH abuse on some biochemical variables in addicted individuals. Study design: One hundred and twenty participants were split into three groups for the study: forty men without addiction (R1), who were not smokers or people with long-term illnesses; forty methamphetamine addicts (R2); and forty methamphetamine and other narcotic substance (mixture) addicts (R3). The participants' ages ranged from 18 to 50 years, and their duration of methamphetamine abuse was between 1 and 5 years. Results: In comparison to the non-addicted group (R1), the results indicate a significant drop in glucose levels in the addicted group (R2, R3) (P < 0.05). The levels of ALT and AST were significantly higher in the addicted group (R2, R3) than in the non-addicted group (R1) (P < 0.05). When compared to the non-addicted group (G1), calcium levels were noticeably greater in the addicted group (R2, R3) (P < 0.05). The addicted group (R2, R33) had significantly higher sodium levels than the non-addicted group (R1) (P < 0.05). | ||
| Keywords | ||
| Biochemical variables; methamphetamine; methamphetamine addicts | ||
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