KIF20A immunohistochemical expression in urothelial carcinoma of urinary bladder in Egyptian patients
El Sayed Abd Allah, D., Elhanbouli, H., Khattab, H., Nabil, D. (2025). KIF20A immunohistochemical expression in urothelial carcinoma of urinary bladder in Egyptian patients. EKB Journal Management System, 16(1), 31-38. doi: 10.21608/fumj.2025.366656.1474
Dina Gamal El Sayed Abd Allah; Hala Elhanbouli; Hani Mahmoud Khattab; Dalia Nabil. "KIF20A immunohistochemical expression in urothelial carcinoma of urinary bladder in Egyptian patients". EKB Journal Management System, 16, 1, 2025, 31-38. doi: 10.21608/fumj.2025.366656.1474
El Sayed Abd Allah, D., Elhanbouli, H., Khattab, H., Nabil, D. (2025). 'KIF20A immunohistochemical expression in urothelial carcinoma of urinary bladder in Egyptian patients', EKB Journal Management System, 16(1), pp. 31-38. doi: 10.21608/fumj.2025.366656.1474
El Sayed Abd Allah, D., Elhanbouli, H., Khattab, H., Nabil, D. KIF20A immunohistochemical expression in urothelial carcinoma of urinary bladder in Egyptian patients. EKB Journal Management System, 2025; 16(1): 31-38. doi: 10.21608/fumj.2025.366656.1474

KIF20A immunohistochemical expression in urothelial carcinoma of urinary bladder in Egyptian patients

Fayoum University Medical Journal
Volume 16, Issue 1, November 2025, Pages 31-38    PDF (1.22 M)
Document Type: Review Articles
DOI: 10.21608/fumj.2025.366656.1474
Authors
Dina Gamal El Sayed Abd Allah* 1; Hala Elhanbouli2; Hani Mahmoud Khattab3; Dalia Nabil4
1Anatomic Pathology Department, Faculty of medicine, Fayoum university, Fayoum, Egypt
2Anatomic Pathology Department, Faculty of medicine, Fayoum University, Fayoum, Egypt
3Anatomic Pathology Department, Faculty of medicine, Cairo University ,Cairo, Egypt
4Anatomic Pathology department, Faculty of medicine Fayoum University, Fayoum, Egypt
Abstract
Introduction: Urothelial bladder cancer, a prevalent malignancy worldwide, poses significant challenges in diagnosis and prognosis due to its complex and multifactorial etiology.
Aim of the study: This article comprehensively studies the production of Kinesin family member 20A (KIF20A), a well-established oncogene implicated in various human cancers, within the context of urothelial bladder carcinoma. Furthermore, we sought to study potential correlations of KIF20A production to a range of clinicopathological parameters to evaluate its utility as a diagnostic or prognostic biomarker.
Subjects and Methods: Immunohistochemical analysis of KIF20A was conducted on a cohort of 60 archived paraffin-embedded bladder cancer tissue samples.
Results: Our findings revealed high KIF20A expression in 60% (36/60) of the cases, exhibiting both cytoplasmic and membranous staining patterns. KIF20A expression showed significant correlations with several clinicopathological factors. A strong association was observed with tumor grade (p=0.001) and pathological T stage (p=0.001). Vascular embolism also correlated significantly with KIF20A expression (p=0.000), as did perineural invasion (p=0.025). Furthermore, KIF20A expression levels were significantly associated with tumor location within the bladder (p=0.027).
Conclusion: These results introduces KIF20A as a valuable biomarker for bladder cancer, potentially aiding in risk stratification and treatment decision-making.
Keywords
KIF20A; Immunohistochemistry; Bladder carcinoma
Statistics
Article View: 4
PDF Download: 6