Prediction of Non-Alcoholic Fatty Liver Disease Using Triglycerides/ Fasting Blood Glucose Index in Type 2 Diabetic Patients | ||
| The Medical Journal of Cairo University | ||
| Volume 93, Issue 09, September 2025, Pages 1213-1223 PDF (223.61 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjcu.2025.464434 | ||
| Author | ||
| KHOLOUD ABDELGHANI, M.D.; AMR MANSOUR SAVED, M.Sc. OMAR HEIKAL, M.D. | ||
| The Department of Internal Medicine, Faculty of Medicine Misr University for Science and Technology MUS | ||
| Abstract | ||
| Background: Since NAFLD is a growing global public health concern and is the most common cause of chronic liv-er disease worldwide and has a strong associated with insulin resistance, metabolic syndrome, and type 2 diabetes melli-tus, also being a multisystemic disease early identification of NAFLD in high-risk population is necessary. NAFLD also has no specific clinical manifestations, so diagnosing the disease early is difficult. A liver biopsy is the “gold standard” to diag-nose NAFLD, but its complications limit its use Therefore, it was important to identify a proper marker for early diagnosis, evaluation, and prognosis of NAFLD. Aim of Study: This study aims to use the triglyceride–glu-cose (TyG) index as an ideal marker for early detection of NAFLD in type 2 diabetic patients. Comparing the sensitivity of (TyG) index to (FLI) in early prediction of Non-alcoholic Fatty liver disease. Patients and Methods: This case-control study involved 188 individuals aged 18 to 70 who attended the Internal med-icine clinic at Saud Kafafy University Hospital and National Hepatology and Tropical Medicine institute. Approval of the ethical committee was granted before starting the work. The study will span a period of time from August 2023 to Decem-ber 2024. Results: This study included 188 individuals classified ac-cording to body mass index into two groups, each included 94 individuals: Group I (NAFLD group), Group II (non-NAFLD group). Our results showed that the TyG index, HOMA-IR, and FLI were all significantly elevated in the NAFLD group, reinforcing their utility in identifying NAFLD. Correlations showed that these indices were strongly associated with waist circumference, BMI, FBG, triglycerides, and liver enzyme levels. Notably, the TyG index exhibited the highest diagnos-tic accuracy with an AUC of 0.838, followed by FLI (AUC = 0.766) and HOMA-IR (AUC = 0.593). The NAFLD group’s mean TyG index (9.3±0.6) was significantly higher than the non-NAFLD group (8.6±0.3) (p<0.001). This robust distinc-tion highlights the diagnostic reliability of the TyG index. Conclusion: According to our study, the TyG index is a trustworthy method for identifying people who are at risk of NAFLD since it performs better than other indices like FLI and HOMA-IR in terms of diagnostic accuracy, specificity, and positive predictive value. | ||
| Keywords | ||
| NAFLD; Type 2 Diabetic patients; TyG index; FLI index | ||
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