Role and Relationship of Immunoglobulin M with Aminotransferase Enzyme in Patients with Hepatitis A
Hussein, B., MOHAMMED, Z., Malih, Z., Taher, A., Bohan, H. (2025). Role and Relationship of Immunoglobulin M with Aminotransferase Enzyme in Patients with Hepatitis A. EKB Journal Management System, (), 1091-110. doi: 10.21608/jbaar.2025.464450
Bashar J Hussein; ZAHRAA KADHIM MOHAMMED; Zainab M. Malih; Aya Y. Taher; Hayder H. Bohan. "Role and Relationship of Immunoglobulin M with Aminotransferase Enzyme in Patients with Hepatitis A". EKB Journal Management System, , , 2025, 1091-110. doi: 10.21608/jbaar.2025.464450
Hussein, B., MOHAMMED, Z., Malih, Z., Taher, A., Bohan, H. (2025). 'Role and Relationship of Immunoglobulin M with Aminotransferase Enzyme in Patients with Hepatitis A', EKB Journal Management System, (), pp. 1091-110. doi: 10.21608/jbaar.2025.464450
Hussein, B., MOHAMMED, Z., Malih, Z., Taher, A., Bohan, H. Role and Relationship of Immunoglobulin M with Aminotransferase Enzyme in Patients with Hepatitis A. EKB Journal Management System, 2025; (): 1091-110. doi: 10.21608/jbaar.2025.464450

Role and Relationship of Immunoglobulin M with Aminotransferase Enzyme in Patients with Hepatitis A

Journal of Bioscience and Applied Research
Articles in Press, Corrected Proof, Available Online from 06 November 2025    PDF (466.57 K)
Document Type: Original Article
DOI: 10.21608/jbaar.2025.464450
Authors
Bashar J Hussein* 1; ZAHRAA KADHIM MOHAMMED2; Zainab M. Malih2; Aya Y. Taher2; Hayder H. Bohan3
1Department of Chemistry and Biochemistry, College of Medicine, Al-Iraqia University, Baghdad, IRQ
2Department of Chemistry and Biochemistry, University of Al-Iraqia, College of Medicine, Baghdad, IRQ
3Department of Surgery, College of Medicine, Al-Iraqia University, IRQ
Abstract
Background:  Hepatitis A virus (HAV) contamination causes liver irritation, resulting in improved aminotransferase enzyme levels. Objectives: This study aimed to investigate the correlation among HAV-particular immunoglobulin M (IgM) antibodies and liver enzyme activity, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total serum bilirubin (TSB), across varying ranges of ailment severity. Method: A total of 170 sufferers with HAV contamination have been categorized into mild (n = 60), moderate (n = 25), and severe (n =85) organizations. Serological exams (HAV IgM) and liver characteristic tests were performed. Result: Significant increase in ALT, AST, and TSB levels has been determined with sickness severity (p < 0.0001 and p = 0.003, respectively), even as ALP showed no large variation (p = 0.967). Correlation evaluation discovered strong, high-quality relationships between HAV IgM degrees and ALT (r = 0.648, p < 0.0001) and AST (r = 0.523, p < 0.0001); however, no association with ALP (r = 0.1/2, p = 0.943). Conclusion: These findings recommend that ALT and AST are reliable biomarkers for assessing liver harm severity in HAV infections, while HAV IgM levels may also function as a trademark of ailment development. The study underscores the significance of habitual monitoring of aminotransferase enzymes and HAV IgM levels in coping with HAV patients. Future research needs to focus on longitudinal research to validate these findings and investigate the underlying mechanisms of HAV-brought liver damage.
Keywords
Liver Function Tests (LFTs); AST; ALT; Immunoglobulin M (IgM)
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