Assessment of intestinal free fatty acid binding protein 4 (FABP4) in alopecia areata patients (Role of intestinal free fatty acid binding protein 4 in dermatological diseases) | ||
| Fayoum University Medical Journal | ||
| Volume 16, Issue 1, November 2025, Pages 39-49 PDF (728.75 K) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/fumj.2025.373273.1494 | ||
| Authors | ||
| Ghada Abdeltwab Ali* 1; Talal Ahmed Abd El Raheem2; Olfat Gamil Shaker3; sara Magdy Yaseen4 | ||
| 1Dermatology department, faculty of medicine, Fayoum University, Fayoum, Egypt | ||
| 2Dermatology Department, Faculty of Medicine, Cairo University , Egypt. | ||
| 3Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo | ||
| 4Dermatology department, Fayoum University | ||
| Abstract | ||
| Abstract Introduction: Intestinal free fatty acid binding protein 4 (FABP4) has emerged as a significant biomarker in dermatological diseases due to its roles in lipid metabolism, inflammation, and oxidative stress. FABP4 is implicated in conditions such as psoriasis, alopecia areata, vitiligo, and acne vulgaris, reflecting systemic inflammation and metabolic disturbances Aim of the study: To assess the levels of FABP4 in the dermatological diseases and determine its role in the pathogenesis of theses condition Subjects and Methods: We searched Cochrane, Web of Science, PubMed, and SCOPUS for relevant articles. We utilized a strategy for our search by combining these keywords: (‘’ FABP4’’ OR ‘’ IL-6’’) AND (‘’ interleukin-17’’ OR ‘’ IL-17’’) AND (‘’ Acne Vulgaris ‘’ OR ‘’ psoriasis ‘’ OR ‘’ dermatological diseases ‘’ OR ‘’ alopecia areata ‘’ OR ‘’ vitiligo ‘’). Quality evaluation of the involved studies was assessed regarding to Cochrane’s risk of bias tool. Results: we found that patients suffered from acne vulgaris, psoriasis, vitiligo, and alopecia areata showed significantly higher FABP4 level than healthy individuals (P < 0.001). Additionally, significantly higher level of FABP4 were detected in individuals with severe lesions than those with moderate and mild lesions (P < 0.001). Conclusions: FABP4 serves as a significant link between lipid metabolism, inflammation, and oxidative stress, making it a crucial factor in the pathogenesis of psoriasis, alopecia areata, vitiligo, and acne vulgaris. Keywords: Acne vulgaris, psoriasis, vitiligo, alopecia areata, AV, AA, FABP4. | ||
| Keywords | ||
| Acne vulgaris; psoriasis; vitiligo; alopecia areata; FABP4 | ||
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