The Impact of Autoimmune Thyroiditis on Thyroid Function, Lipid Profile, and Glycaemic Control in Patients with Type 2 Diabetes Mellitus | ||
| Fayoum University Medical Journal | ||
| Volume 16, Issue 1, November 2025, Pages 109-122 PDF (922.47 K) | ||
| Document Type: Full Length research Papers | ||
| DOI: 10.21608/fumj.2025.384266.1520 | ||
| Author | ||
| Sarmad Alrubaye* | ||
| College of Medicine, University of Al-Ameed, Kerbala, Iraq | ||
| Abstract | ||
| Aim: to explore the role of AT in thyroid dysfunction, dyslipidaemia and glycaemic control in T2DM patients. Also, to investigate the associations between different clinical and laboratory data with AT in the study groups. Methods: This is a cross-sectional study included 150 T2DM patients attending Al-Hussein Teaching Hospital, Kerbala, Iraq and 50 individuals included as a healthy control group. Full history and physical examination were performed for all subjects, body mass index (BMI) was determined in all individuals. Blood samples were collected to evaluate laboratory parameters including thyroid autoantibodies (anti-TPO and anti-Tg), thyroid function tests, glycemic control indices and lipid profiles. The thyroid gland size was measured by ultrasonography. Results: From 150 T2DM patients included in the study, 62 (41.3%) were found to have AT and 88 patients with T2DM alone. The AT+T2DM group had significantly higher BMI (33.89±5.59 kg/m²) and larger thyroid size (29.22±8.84 mL) than those of T2DM and control groups (p < 0.0001). The AT+T2DM group had bad glycaemic control, represented by a significant higher HbA1c (13.27±5.02%) and FBG (160.72±19.09 mg/dL) than those in other tested groups (p < 0.0001). Lipid profile was significantly higher in the AT+T2DM group than other tested groups (p <0.0001). Thyroid autoantibodies had significant positive correlations with HbA1c, TG, and AI, and negative correlations with FT3, FT4, and HDL-c (p < 0.01). Conclusion: Individuals with T2DM with AT have a higher prevalence of thyroid dysfunction, poorer glycemic control, and a significantly higher lipid profile than patients without AT and non-diabetic controls. | ||
| Keywords | ||
| Autoimmune thyroiditis; Type 2 diabetes mellitus (T2DM); Thyroid dysfunction, glycaemic control; Lipid profile | ||
|
Statistics Article View: 14 PDF Download: 9 |
||
