Altered Serum Cytokines Profile in Patients with Myasthenia Gravis | ||
| Egyptian Journal of Medical Microbiology | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 July 2026 PDF (1.06 M) | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2025.438147.1968 | ||
| Authors | ||
| Rasha M. Elnagar1; Nouran E. Samra2; Safaa M. Elageery* 2; Nawal S. Gouda3; Enas Gouda4; Amal M. Hammad5; Mazen M. Eladaroussy6; Aya Zhran7; Rania Talaat8 | ||
| 1Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt; Basic Medical Sciences Department, College of Medicine, Al-Maarefa University, P.O.Box71666, Riyadh 11597, Saudi Arabia | ||
| 2Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Egypt | ||
| 3Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Egypt; Medical Microbiology and Immunology Department, Faculty of Medicine, Northern Border University, Saudi Arabia | ||
| 4Clinical Pathology Department, Hematology Unit, Faculty of Medicine, Mansoura University, Egypt | ||
| 5Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Al-Azhar University, Damietta, Egypt | ||
| 6MBBCH, Faculty of Medicine, Mansoura University, Egypt | ||
| 7Neurology Department, Faculty of Medicine, Mansoura University | ||
| 8Medical Microbiology and Immunology Department, Faculty of Medicine, Helwan University | ||
| Abstract | ||
| Background: One of the most common neuromuscular junction disorders is autoimmune myasthenia gravis (MG). Cytokines profile is expected to be of most important in MG pathogenesis. Objectives: In this research we aimed to analyze serum cytokines profiles in acetylcholine receptor (AChR) antibody positive MG patients and determine the link between these cytokines and clinical parameters of MG. Methodology: Forty AChR antibody positive MG patients and 40 healthy participants (HC) were included in this study. Serum cytokines including IL-2, IL-4, IL-6, IL-15, IL-17 A, IFN-γ, were measured by enzyme linked immunosorbent assay (ELISA). The correlations between serum cytokines levels and clinical profile were analyzed. Results: Serum levels of IL-6, IL-15, IL-17 were significantly higher in MG patients than in HC. Serum levels of IL-4 were significantly lower in MG patients than in HC. According to MG Foundation of America (MGFA) classification, generalized MG group (G-MG) had higher levels of IL-6 and IL-17 than HC, without statistical significant variation among oculomotor MG (O-MG) and HC. We also found that early onset MG (EOMG) had significantly higher IL-2 levels compared to late onset MG (LOMG). We also found significant higher IL-17 levels in thymoma associated MG patients (TMAG) than in MG with normal thymus group. Serum levels of IL-6 and IL 17 were positively correlated with AChR antibodies concentration and quantitative MG (QMG) scores in all MG patients. Conclusion: we can conclude that the pathogenic inflammatory effects exerted by cytokines at neuromuscular junctions are important in MG patients. | ||
| Keywords | ||
| serum cytokines; myasthenia gravis; ELISA | ||
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