Influence of Galangal Root Oil on Some Heat Shock Proteins and Antioxidant Enzymes in H2O2-Induced Hepatic Damage in Rats | ||
| Egyptian Academic Journal of Biological Sciences, B. Zoology | ||
| Volume 17, Issue 2, December 2025, Pages 153-164 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsz.2025.464859 | ||
| Authors | ||
| Raya Ghassan1; Ali S. Alchalabi2; Waad S. Shaher3 | ||
| 1Department of biology, Education college for Women, University of Mosul, Mosul, Iraq. | ||
| 2Department of clinical laboratory science, College of Pharmacy, University of Mosul, Mosul, Iraq. | ||
| 3Department of biology, College of Science, University of Mosul, Mosul, Iraq. | ||
| Abstract | ||
| The study examined how Galangal root oil affected heat shock proteins (HSPs) and antioxidant enzymes in rats with H2O2-induced liver injury. 24 adult male rats 200-230g BW were randomly assigned to four groups: the control group received 0.1 N.S. orally, and three treatment groups: Group 1 (G1) had liver damage from daily 2.5% H2O2 in drinking water, with water replaced twice daily after two weeks of acclimation. Group 2 (G2) got 0.2 ml of 100% Pure Therapeutic Grade Galangal Root Oil (GRO) orally each rat. Group 3 (G3) received 0.2 ml GRO/ H2O2. The trial lasted 30 days. Molecular analysis was performed on liver samples after the trial. H2O2 increased HSPs and decreased antioxidant enzyme expression throughout the research. This impact is enhanced by GRO alone/with H2O2. It was found that 2.5% H2O2 exposure has serious biological effects, while galangal root oil protects hepatocytes from severe oxidative stress via modifying heat shock protein and antioxidant enzyme regulatory genes. | ||
| Keywords | ||
| Heat shock proteins; Antioxidant enzymes; Gene expression; Galangal Root oil; hepatic changes | ||
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