Helicobacter Pylori Infection among Children with Chronic Liver Diseases
Behairy, B., Saber, M., Abd El-Aziz, A., Elbadawy, Z., Elkholy, S., Salem, T. (2025). Helicobacter Pylori Infection among Children with Chronic Liver Diseases. EKB Journal Management System, 6(4), 96-123. doi: 10.21608/ejmr.2025.389299.1837
Behairy E. Behairy; Magdy A. Saber; Azza M. Abd El-Aziz; Zaynab M. Elbadawy; Shymaa S. Elkholy; Tahany A. Salem. "Helicobacter Pylori Infection among Children with Chronic Liver Diseases". EKB Journal Management System, 6, 4, 2025, 96-123. doi: 10.21608/ejmr.2025.389299.1837
Behairy, B., Saber, M., Abd El-Aziz, A., Elbadawy, Z., Elkholy, S., Salem, T. (2025). 'Helicobacter Pylori Infection among Children with Chronic Liver Diseases', EKB Journal Management System, 6(4), pp. 96-123. doi: 10.21608/ejmr.2025.389299.1837
Behairy, B., Saber, M., Abd El-Aziz, A., Elbadawy, Z., Elkholy, S., Salem, T. Helicobacter Pylori Infection among Children with Chronic Liver Diseases. EKB Journal Management System, 2025; 6(4): 96-123. doi: 10.21608/ejmr.2025.389299.1837

Helicobacter Pylori Infection among Children with Chronic Liver Diseases

Egyptian Journal of Medical Research
Volume 6, Issue 4, October 2025, Pages 96-123    PDF (700.21 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2025.389299.1837
Authors
Behairy E. Behairy1; Magdy A. Saber2; Azza M. Abd El-Aziz3; Zaynab M. Elbadawy* 4; Shymaa S. Elkholy5; Tahany A. Salem2
1Professor of Pediatric Hepatology, Gastroenterology and Nutrition Department, National liver Institute, Menoufia University, Shebin El-koom, Egypt.
2Assistant Professor of Pediatric Hepatology, Gastroenterology and Nutrition Department, National liver Institute, Menoufia University, Shebin El-koom, Egypt.
3Professor of Clinical and Molecular Microbiology & Immunology Department, National liver Institute, Menoufia University, Shebin El-koom, Egypt.
4Resident of Pediatric Hepatology, Gastroenterology and Nutrition Department, National liver Institute, Menoufia University, Shebin El-koom, Egypt.
5Lecturer of Pathology Department, National Liver Institute, Menoufia University, Shebin El-koom, Egypt.
Abstract
Background: Helicobacter pylori (H.pylori) infection is a gastrointestinal pathogen with emerging evidence linking it to chronic liver diseases (CLD).  Aim: To investigate the prevalence of H. pylori infection among children with CLD, its endoscopic and histopathological associations, and its effect on disease severity and severity of bleeding. Methods: This cross-sectional study included 63 children diagnosed with CLD at the National Liver Institute, Menoufia University, Egypt. Patients were categorized into H. pylori-positive and H. pylori-negative groups. All patients underwent gastrointestinal endoscopy, with histopathological examination and H. pylori stool antigen in stools. Demographic, clinical, laboratory, endoscopic, and histopathological findings were analyzed. Results: H. pylori-positive patients showed higher prevalence of abdominal pain, dyspepsia, anemia, melena, and hematemesis (P < 0.05). H. pylori infection was significantly associated with lower hemoglobin and elevated liver enzymes: ALT (89.3% vs. 62.9%, P = 0.000), AST (75% vs. 37.14%, P = 0.003), and total serum bilirubin (92.86% vs. 51.43%, P < 0.001). Endoscopic findings showed a significant association with gastritis (P = 0.007) and gastric nodularity (P = 0.006) in H. pylori-positive patient. A significantly higher infiltration of inflammatory cells and lymphoid follicle formation in both duodenal and gastric biopsies of H. pylori-positive patients. The need for intervention (sclerotherapy/banding) was significantly higher in H. pylori-positive patients. GBS was not statistically different between the two groups.  Conclusion: H. pylori infection in children with CLD was associated with a higher prevalence of gastritis, gastric nodularity, and increased gastrointestinal bleeding symptoms with increased rates of sclerotherapy/banding in patient with CLD.
Keywords
Chronic Liver Disease; Children; Endoscopy; Helicobacter Pylori; Histopathology
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