Assessment of the Antibacterial Potential of Aloe Vera Extracts Against Bacterial Isolates from Wound Infections | ||
| Microbes and Infectious Diseases | ||
| Articles in Press, Accepted Manuscript, Available Online from 09 November 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mid.2025.432430.3331 | ||
| Authors | ||
| safaa said hammad* 1; Hanaa bhaaeldeen elkhouly2; sara Ibraheem sayed3; Mohammed Zain-Alabedeen Abdel Kareem4 | ||
| 1Microbiology and Immunology Department, Faculty of Medicine, Minia university, Egypt | ||
| 2Department of Pharmaceuticals, Faculty of Pharmacy, Minia University, Egypt | ||
| 3Department of Public Health and Preventive Medicine, Faculty of Medicine, Minia University, Egypt | ||
| 4Microbiology and Immunology Department, Faculty of Medicine Al-Azhar University, Assiut, Egypt | ||
| Abstract | ||
| Background: The rapid development of microbial resistance to chemotherapeutic agents, particularly antibiotics, necessitates the screening of effective, safe, affordable, and accessible therapeutics derived from various medicinal plants. Aloe vera is a recognized medicinal plant utilized for various therapeutic applications. objectives: To evaluate the antibacterial activity of ethanol extracts of Aloe vera leaves against bacterial strains isolated from patients with wound infections, providing effective, safe, affordable, and accessible therapeutics of natural origin. Methods: In this cross- sectional study, sixty samples were collected from septic wounds. The bacterial isolates were identified based on colony characteristics, Gram staining, and standard biochemical tests. The isolates were then tested for antibiotic resistance against five clinically significant antibiotics, and the antibacterial activity of Aloe vera leaf gel ethanol extract (prepared using two different extraction methods) was evaluated using disk diffusion and well diffusion techniques. Results: Four bacterial species were isolated from sixty wound infection samples, with Staphylococcus aureus accounting for 66.7%, Pseudomonas aeruginosa for 12%, Escherichia coli for 6.7%, and Klebsiella species for 6.7%. Aloe vera ethanol extract (A) showed the highest antibacterial activity, with 76.7% of isolates sensitive, while extract (B) showed 46.7% sensitivity. Aloe vera extract (A) exhibited strong activity against both Gram-positive and Gram-negative bacteria, suggesting its potential as a complementary or alternative antimicrobial agent for wound infections. Conclusion: This study supports the idea that Aloe vera leaf extracts possess significant antibacterial potential and could serve as an effective natural alternative or adjunct therapy for managing microbial wound infections. | ||
| Keywords | ||
| Wound infections; Bacteria; Antibiotic sensitivity; Plant extracts; Antibacterial activity | ||
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