Deregulated serum levels of Serpin C and Soluble fms-like tyrosine kinase-1 might predict the development of Preeclampsia in Normotensive Pregnant Women | ||
| Benha Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 10 November 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2025.372488.2356 | ||
| Authors | ||
| Omar K. Naser* 1; Ahmed S. Yassin2; Ahmed G. Goda3; Amira E. Khalil4 | ||
| 1Obstetrics and Gynecology department, Benha faculty of medicine, Benha university, Benha, Egypt | ||
| 2Obstetrics and Gynecology department, Benha faculty of medicine, Benha University, Benha, Egypt | ||
| 3Obstetrics and Gynecology depatment, Benha Faculty of medicine Benha University Egypt | ||
| 4Obstetrics and Gynecology department, Benha Faculty of Medicine, Benha University, Benha, Egypt | ||
| Abstract | ||
| Objectives included the evaluation of performance of estimating Serpin C, placental growth factor (PLGF), and soluble fms-like tyrosine kinase 1 (sFlt-1) in serum samples obtained early in pregnancy in samples of normotensive (NT) pregnant women to identify those liable to develop Gestational hypertension (GHTN) or preeclampsia (PE) and to discriminate the risky women for early-onset PE (EO-PE). Methods: blood samples obtained from 225 NT pregnant women for chemical pregnancy diagnosis were stored for ELISA estimation of the studied biomarkers. Blood pressure (BP) measures were recorded monthly. Results: During follow-up, 66 and 47 women developed GHTN and PE, respectively, and 12 of the preeclamptic women had EO-PE. Estimated levels of Serpin C and PLGF were markedly decreased, while serum sFlt-1 levels were highly increased with an elevated sFlt-1/PLGF ratio in PE than in GHTN and in GHTN than NT women. Statistical analyses defined low serum Serpin C and high sFlt-1/PLGF ratio in early pregnancy as a predictor for the oncoming hypertensive disorders, but serum Serpin C is a significant identifier for women liable to have EO-PE. Conclusion: Low serum Serpin C in conjunction with deregulated sFlt-1/PLGF ratio or its constituents in samples obtained from NT women early during pregnancy might discriminate women vulnerable to developing gestational hypertensive disorders, but low serum Serpin C could identify risky women for EO-PE. | ||
| Keywords | ||
| Gestational hypertension; Early-onset preeclampsia; Serpin C; Placental growth factor; soluble fms-like tyrosine kinase 1 (sFlt-1) | ||
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