Association of CD93 and CHI3L1 Gene Polymorphisms with Hepatocellular Carcinoma | ||
| Egyptian Journal of Medical Microbiology | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 July 2026 PDF (420.5 K) | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2025.433620.1941 | ||
| Authors | ||
| SARA K. Rizk* 1; Samah El-Ghlban2; Walaa Shaheen3; Abdallah Abdelatef4 | ||
| 1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine Menofia University, shebin Elkom- Egypt | ||
| 2Biochemistry Division, Department of Chemistry, Faculty of Science Menoufia University, Shebin El-kom, Egypt | ||
| 3Tropical Medicine Department, Faculty of Medicine Menoufia University, Shebin El-kom, Egypt | ||
| 4Microbiology and Chemistry Department- Al-Azhar University- Egypt | ||
| Abstract | ||
| Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, particularly in regions with high prevalence of chronic hepatitis B and C infections. Chitinase-3-like protein 1 (CHI3L1) has been implicated in inflammation, fibrosis, and tumor progression. Similarly, cluster of differentiation 93 (CD93), a glycoprotein involved in angiogenesis and immune regulation, is overexpressed in several cancers. Objective: This Study aims to investigate associations between CHI3L1 (rs880633) and CD93 (rs2749817) gene polymorphisms and the risk of developing HCC in Egyptian patients with chronic hepatitis B or C. Methodology: This case-control study included 48 HCC patients (23 with HCC on top of HCV and 25 with HBV-related HCC) in addition to 48 age- and sex-matched healthy controls. Clinical evaluation, laboratory tests, and genotyping for rs880633 and rs2749817 were performed using TaqMan® real-time PCR. Genotype and allele frequencies were compared, and logistic regression analyses were conducted to identify predictors of HCC risk. Results: The TC genotype of rs880633 was significantly more frequent in HCC cases than controls (52.1% vs. 35.4%, p=0.044), with carriers showing 2.42-fold increased HCC risk (OR=2.422, 95% CI: 1.023–5.735). The C allele was also associated with higher HCC risk (p=0.030, OR=1.990, 95% CI: 1.067–3.713). Conversely, rs2749817 showed no significant association with HCC susceptibility (genotype p>0.05). In multivariate analysis, SNP (rs880633) independently predicted HCC risk. Conclusion: CHI3L1 rs880633 polymorphism is associated with increased susceptibility to HCC in Egyptian patients with viral hepatitis, highlighting its potential as a genetic risk marker. | ||
| Keywords | ||
| CHI3L1; CD93; SNP; Viral hepatitis; Real Time PCR | ||
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