The Clinical Utility of Lactate/Albumin Ratio as an Early Prognostic Marker of Intensive Care Unit Mortality: A Prospective Observational Study | ||
| Medicine Updates | ||
| Articles in Press, Accepted Manuscript, Available Online from 12 November 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/muj.2025.435131.1277 | ||
| Authors | ||
| Mohammed Raslan El-Sayed* 1; Magdy Ali Omera2; Nashwa Ahmed3 | ||
| 1Resident of Anesthesia and Intensive Care Department, Faculty of Medicine, Military Hospitals, Egypt | ||
| 2Professor of Anesthesia and Intensive Care Department, Faculty of Medicine, Port Said University, Port Said, Egypt | ||
| 3Lecturer of Anesthesia and Intensive Care Department, Faculty of Medicine, Port Said University, Port Said, Egypt | ||
| Abstract | ||
| Background: The lactate/albumin (L/A) ratio is considered to be a superior prognostic indicator due to its correlation with death and multiorgan failure in severe sepsis. Aim of study: To evaluate and analyze predictive value of L/A ratio as a mortality indicator in patients with septic shock. Materials and Methods: This prospective observational study was involved 50 patients suffered from septic shock rendering to criteria established by Third International Consensus Definitions for Septic Shock (Sepsis-3) at Intensive Care Unit of Alexandria Armed Forces Medical Complex. All subjects were alienated into both groups according to existence at end of study: Group I (n= 24): was survivors and Group II (n= 26): was non survivors. All patients underwent a comprehensive initial clinical assessment. Results: Receiver operating characteristic curve analysis confirmed that procalcitonin had the highest predictive accuracy for intensive care unit mortality with an area under curve (AUC) of 0.872 (95% CI: 0.765–0.979, p < 0.001), sensitivity of 92%, and specificity of 90%. L/A ratio also showed strong discriminatory ability (AUC = 0.853, 95% CI: 0.744–0.961, p < 0.001) with sensitivity 90% and specificity 87%, followed by lactate (AUC = 0.824, 95% CI: 0.698–0.950, p < 0.001). Conclusion: A prognostic biomarker for mortality prediction in septic shock cases is L/A ratio, which is highly effective, showing superior discriminatory ability compared to traditional severity scores like SOFA and APACHE II. | ||
| Keywords | ||
| Clinical Utility; Early Prognostic Marker; Intensive Care Unit; Lactate/Albumin Ratio; Mortality | ||
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