The possible ameliorative effect of Nicorandil on acute paracetamol-induced hepatotoxicity in albino rats | ||
| Minia Journal of Medical Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 12 November 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2025.437274.2122 | ||
| Authors | ||
| Llian Nashed Balash* 1; Morid Malak Hanna2; Alshaimaa Wagdy Qassem3; Asmaa Mohamed Mahmoud Ali4 | ||
| 1Toxicology resident at department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Minia University, Minia, Egypt. | ||
| 2Professor of Forensic Medicine & Toxicology Faculty of Medicine - Minia University | ||
| 3Lecturer of Pathology Faculty of Medicine - Minia University | ||
| 4Lecturer of Clinical Toxicology Faculty of Medicine - Minia University | ||
| Abstract | ||
| Background: Paracetamol intoxication is one of the major causes of acute liver injury, contributing significantly to patient morbidity and mortality. While N-acetylcysteine remains the standard treatment for hepatotoxicity, other effective therapeutic options for paracetamol-induced hepatotoxicity are present. Nicorandil, a K+ channel opener and a NO donor with vasodilatory properties, has established antioxidant, antiapoptotic and anti-inflammatory effects. The Aim of the work: The study aims to determine if nicorandil might ameliorate hepatotoxicity due to paracetamol intoxication in adult male albino rats. Material and Methods: Sixty adult male albino rats were used and divided to 6 groups (group I the control group , group II nicorandil-treated group, group III paracetamol-treated group, group IV paracetamol plus NAC-treated group, group V paracetamol plus nicorandil-treated group and group VI paracetamol plus NAC and nicorandil-treated group). Liver function tests and hepatic (catalase, MDA, NO and nuclear factor erythroid 2- related factor 2) levels were estimated. Histological and immunohistochemical examination of hepatic tissues were also done. Results: The findings revealed significant increase in liver functions tests, MDA & NO and significant decrease in catalase and Nrf2 levels in paracetamol-treated group. Paracetamol caused marked histological changes in liver that appeared through histological and immunohistochemical investigations. These changes were ameliorated by nicorandil administration. Conclusion: Nicorandil can ameliorate hepatic damage and alterations occurred by paracetamol intoxication in albino rats. | ||
| Keywords | ||
| Nicorandil; paracetamol; hepatotoxicity; MDA | ||
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