Quantitative CT study of Lobar Distribution of Airway and Emphysema Affection Among COPD patients with the Emphysema Phenotype | ||
| Minia Journal of Medical Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 12 November 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2025.433904.2112 | ||
| Authors | ||
| Taghreed Abdelaziz Nasr* 1; Hosny Abdelghany2; Nasr Mohamed M. Osman3; Azza Farag Said1; Mohamed Ahmed Abdelsamie4 | ||
| 1Radiology department, Faculty of Medicine, Minia university, egypt | ||
| 2Radiology Department, Minia University, Minia, Egypt | ||
| 3Radiology department, faculty of medicine | ||
| 4Radiology, Faculty of Medicine, Minia university, egypt | ||
| Abstract | ||
| Background: Chronic obstructive pulmonary disease (COPD) is the cause of high death rates. The main risk factor is the active smoking. The lower lobe dominant emphysema had more severe airway obstruction compared to those in the upper lobe dominant due to thicker airways as well as more severe air trapping. Methods: 109 patients of emphysema predominant phenotype out of 130 patients with COPD were subjected to full history taking, clinical assessment, Pulmonary function tests and CT examination including quantitative analysis of emphysema with lobar segmentation of low attenuation areas, air way and air trapping quantification. Results: Two groups (upper and lower lobe dominant emphysema groups were categorized depending on the highest %LAA−950value which was determined for each lung separately. The lower lobe dominant emphysema has the lower FEV1% predicted (41.7±8.2 and 36.9±14.3for the right and left lower lung lobes respectively) and higher WA ratio values (45.2±3.5and 46.5±8.5 for the right and left lower lung lobes respectively) than those with upper lobe dominant emphysema. Lower lobe dominant emphysema group has also the lower total LAA−950values (10.8±9.4 and 8.5±8.4 for the right and left lower lung lobes respectively). The lower lung lobes have the higher RVC-860 to −950 values (-19±13 for each of the right and left lower lung lobes). Conclusion: Quantitative CT analysis of patients with COPD helps in prediction of treatment response through detection of the severity of airway involvement. Airways affection was more severe in lower lobe dominant emphysema patients than in those with upper lobe dominant emphysema. | ||
| Keywords | ||
| Emphysema; quantitative assessment; lobar distribution; air way wall thickening; air trapping | ||
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