Malignancies post adult to adult living donor liver transplantation: incidence, risk factors and outcome | ||
| The Egyptian Journal of Surgery | ||
| Volume 44, Issue 4, October 2025, Pages 1225-1232 PDF (373.2 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejsur.2025.364217.1412 | ||
| Authors | ||
| Mohamed Osama* 1; Ashraf Amin Abd El-Aziz2; Mohammed Bahaa El-din Ahmed3; Iman Fawzy Montasser4; Hend Elsaid Ebada3 | ||
| 1Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||
| 2Departments of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt. | ||
| 3Departments of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt. | ||
| 4Departments of General Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt. | ||
| Abstract | ||
| Background: Differential considerations for malignancies in the transplanted liver include recurrent primary liver tumours such as hepatocellular carcinoma (HCC) and de novo malignancies (DNM) such as lymphoproliferative disorder (PTLD), skin malignancy. This study aimed to identify Incidence of malignancy post LDLT in Egyptian recipients including recurrent HCC and/ or DNM and to identify possible risk factors of malignancy post LDLT and outcome. Patients and Methods: Combined retrospective & prospective cohort-cross sectional study that included all medical records of all patients who underwent LDLT, at Ain Shams Center of Organ Transplantation (ASCOT), during the period from 2008 till December 2023, recorded & analyzed then follow up till December 2024. Results: 428 patients; subdivided into Group 1(152 patients) including all patients underwent LDLT due to HCC (subdivided into group 1a (20 patients) > patients who developed recurrent HCC after LDLT & group 1b > non-recurrence group. Group 2 (276 patients). (Subdivided into group 2a (12 patients)> group of DNM & group 2b > not developed DNM. Twenty patients developed recurrent HCC post-LDLT, with a percentage of 13.16% with 5-year survival of 35.7%. The recurrence of HCC after LDLT in our study (group 1a) was mainly extra-hepatic (70%) and early recurrence (65%). The incidence of DNM in our study was 4.3% with 5-year survival of 83.3% and PTLD was the most common DNM. Conclusion: Prevalence of DNM was rare post LDLT (3.4%) &PTLD was most common. recurrence HCC was 13.16% and mainly extrahepatic. | ||
| Keywords | ||
| De novo malignancy; liver transplantation; recurrent HCC | ||
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