Optical and FTIR Spectroscopic Evaluation of Curcumin’s Therapeutic Potential in Experimental Rats Liver Cirrhosis | ||
| International Journal of Theoretical and Applied Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 14 November 2025 PDF (700.92 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ijtar.2025.416841.1142 | ||
| Authors | ||
| gehad zakaria1; Sahar M. Awad* 2; Amira M. Aly3; mohamed hebishy4 | ||
| 1physics, faculty of science, al azhar university | ||
| 2Physics dep. Faculty of Science, Al-Azhar University (Girls Branch) | ||
| 3Physics Department, Faculty of Science, Al-Azhar University ( Girls Branch) | ||
| 4national research center | ||
| Abstract | ||
| Aim of our work is a regression of liver fibrosis and cirrhosis by natural products. Cirrhosis is already a late stage of liver disorders. Our work give more attention about natural herbal remedies as a therapy for liver cirrhosis, due to their plentiful source of antifibrogenic agents as well as their lesser side effects, lower costs, and higher acceptability . Curcumin is a natural compound extractable from turmeric and is widely used in middle eastern diets. Curcumin has an important role in the modulation of many biological mechanisms especially in liver injury. Our work investigates effect of curcumin on curing liver damage in its late stages. Refractive index of plasma was measured in cirrhotic liver, indicating high value due to the presence of high albumin level compared to normal cases while after treatment with curcumin refractive index retained its normal value. Liver’s tissue was also investigated Spectroscopically using FTIR which show shifts of the different bands in FTIR analysis due to curcumin effects and stabilize the group of phosphate and restore normal pattern of hydrogen bonding. Results also showed an improvement in antioxidant behavior due to curcumin injection (which can be considered as a therapeutic agent). There is an improvement in the refraction of plasma because of reduction of oxidative stress, improve protein conformation and decrease protein aggregation. | ||
| Keywords | ||
| Curcumin; liver cirrhosis; herbal therapy; complementary medicine | ||
|
Statistics Article View: 1 PDF Download: 1 |
||
