Outcomes following endovascular stenting for pseudotumor cerebri associated with transverse sinus stenosis | ||
| International Journal of Medical Arts | ||
| Articles in Press, Accepted Manuscript, Available Online from 14 November 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ijma.2025.410836.2244 | ||
| Authors | ||
| Sherif Osama* 1; Mohammed El-Gebaly Ahmed Alhady2; Marawan Abdel Hakam Elsayed Mohammed3 | ||
| 1Resident of Neurosurgery, Al-Azhar University Hospitals, Damietta, Egypt | ||
| 2Neurosurgery Department, Damietta Faculty of Medicine, Al-Azhar University, Egypt | ||
| 3Department of Neurosurgery Damietta Faculty of Medicine, Al-Azhar University | ||
| Abstract | ||
| Background: Idiopathic Intracranial Hypertension (IIH), or Pseudotumor Cerebri (PTC), is a neurological syndrome characterized by elevated intracranial pressure (ICP), headache, and vision loss, predominantly affecting obese women of childbearing age. The aim of the work: this study aimed to determine outcomes of stenting in patients with PTC associated with TS stenosis. Patients and methods: This prospective interventional study evaluated the outcomes of endovascular stenting in 15 patients with PTC associated with transverse sinus stenosis (TSS) who failed medical therapy. Preoperative assessments included neurological, neuro-ophthalmological, and radiological evaluations, with venous stenting performed if a trans-stenotic pressure gradient ≥4 mmHg was documented. Results: Post-stenting outcomes demonstrated significant reductions in pressure gradients: ipsilateral TSS decreased from 20.1 mmHg to 3.1 mmHg (p < 0.001), and contralateral TSS from 15.9 mmHg to 6.7 mmHg (p = 0.007). Symptom improvement was notable, with headaches decreasing in 73.3% of patients and visual disturbances in 53.3%. Medication usage, particularly acetazolamide, declined significantly post-stenting (OR 0.39, p < 0.001). Follow-up imaging confirmed stent patency in 100% of cases, and papilledema improved or resolved in all evaluated patients. Complications were mild, including transient headaches (33.3%) and groin hematoma (13.3%). Conclusion: The study findings suggest that venous sinus stenting is an effective and safe intervention for PTC patients with TSS, offering significant symptom relief and reduced reliance on pharmacotherapy. | ||
| Keywords | ||
| Idiopathic Intracranial Hypertension; Pseudotumor Cerebri; transverse sinus stenosis; venous stenting; intracranial pressure | ||
|
Statistics Article View: 2 |
||
