Effects of | ||
| Microbes and Infectious Diseases | ||
| Articles in Press, Accepted Manuscript, Available Online from 14 November 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mid.2025.430353.3297 | ||
| Authors | ||
| Anmar Azeez Bahidh* ; Dhurgham Ali Alhasan* ; Rabab Shaker Salman* | ||
| Department of Microbiology, College of Veterinary Medicine, University of Shatrah, Iraq | ||
| Abstract | ||
| Background: Rhizopus oryzae is considered one of the fungi that can cause opportunistic mucormycosis. This fungus ranks second among the most significant fungi, following Aspergillus species, in causing fungal infections in humans and animals. Methods: After confirming the identification of R. oryzae, this study tested twenty albino male rats. Ten of the rats were infected with spores of this mold, while the other ten served as a control group. All animals were observed for 30 days, after which they were sacrificed, and their livers were collected for histopathological analysis. Results: The results revealed pathological changes in the livers of the albino male rats infected with R. oryzae. The hepatocytes displayed turbid or granular cytoplasm (indicated by asterisks) and hydropic changes, while some hepatocytes exhibited pyknotic nuclei. The hepatic sections showed significant damage due to an injurious stimulus, with the hepatic cords losing their normal arrangement (indicated by arrows) and displaying irregularities, alongside congested sinusoids (white arrowheads). Additionally, granular material and reactive Kupffer cells were also observed. Conclusion: This study concluded that R. oryzae has detrimental effects on the livers of albino male rats. These findings underscore the harmful impacts that this mold can have, particularly in immunocompromised patients, potentially leading to impaired liver function. | ||
| Keywords | ||
| Rhizopus oryzae; PCR; Male rats; Liver; Experimental infection | ||
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