Protective effects of Echinacea purpurea and vitamin E against linezolid-induced renal damage in rats | ||
| Assiut Veterinary Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 15 November 2025 | ||
| Document Type: Research article | ||
| DOI: 10.21608/avmj.2025.366268.1615 | ||
| Authors | ||
| Hosny A. E. Ibrahim1; Mohamed A. Hashem2; Amany Mohamed Elgerby* 3 | ||
| 1Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511 Egypt. | ||
| 2Clinical Pathology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511 Egypt. | ||
| 3Pharmacology Department , Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511 Egypt. | ||
| Abstract | ||
| The antibiotic linezolid (LNZ) works well against vancomycin-resistant enterococcus and Gram-positive bacteria. Although thrombocytopenia is the most common adverse hematological impact caused by LNZ, pancytopenia is an uncommon complication that can have detrimental consequences on the kidneys. The existing study was planned to inspect the possible protective effect of Echinacea purpurea (immulant) and Vit E alongside some antagonistic belongings of LNZ in rats. This research was accomplished on 35 male rats, two months old, seemingly healthy, weighing 150–200 g, alienated haphazardly into 7 equal groups. The 1st group rats received 0.5 ml/200 g/day/day distilled water (control group), 2nd group received Tween 80 (0.5 ml/200 g/day), 3rd group LNZ (54 mg/kg b.wt), 4th group given Vit E (90 mg/kg b.wt), 5th group received immulant (15.75 mg/kg b.wt), 6th and 7th groups received Vit E+ LNZ, and immulant+ LNZ treated groups respectively at the same doses. Treatments were orally for 14 succeeding days for all groups. LNZ exposure evoked a significant leukopenia, lymphopenia, neutropenia and monocytopenia in rat's blood when compared with the controls. This suppression of linezolid was partially improved by Vit E (gp. 6) or immulant treatments. LZN increased creatinine, urea, Ph and MDA levels in the serum, while serum Ca, SOD, CAT and GPx levels significantly dwindled compared to the control group. Pathologically, kidneys of rats treated with LNZ exhibited tubular epithelial cloudy swelling and hydropic degeneration, dilated collecting tubules and ducts, intra-tubular hyaline and cellular casts, and high caspase expressions in renal tissues compared with other treated groups. | ||
| Keywords | ||
| Linezolid; rats; creatinine; calcium; antioxidants | ||
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