Effect of different media on the production of secondary metabolites with antiviral activity from marine Streptomycetes | ||
| Journal of Basic and Environmental Sciences | ||
| Articles in Press, Accepted Manuscript, Available Online from 15 November 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jbes.2025.433522.1028 | ||
| Authors | ||
| Hadeel Osama* 1; Mohamed A. Nasr El-din2; Radwan Khalil3; Amro Farrag4; Mohamed E. EL-Awady5 | ||
| 1Botany & Microbiology Department, Faculty of science, Benha University, Benha, Egypt | ||
| 2Department of Botany and Microbiology, Faculty of Science, Benha University, Benha 13511, Egypt | ||
| 3Department of Botany and Microbiology, Faculty of Science, Benha University, Benha 13518, Egypt | ||
| 4Virus and Phytoplasma Dept. Plant Pathology Research Institute (PPRI) Agricultural Research Centre (ARC) 9 El Gamaa Street, POBox 12619, Giza, Egypt | ||
| 5Microbial Biotechnology Department, Biotechnology Research Institute, National Research Centre, 33 El-Buhouth St., Dokki, Giza P.O. 12622, Egypt. | ||
| Abstract | ||
| The ability of marine microbes to adapt to adverse conditions is astounding. Making a variety of bioactive substances with various physiological and metabolic characteristics is one method they accomplish this. Their notable contributions to the aquatic ecology are made possible by these modifications, which also guarantee their durability in harsh environments. Therefore, it is expected that the bacteria isolated from marine habitats will be more effective in producing new bioactive compounds. A total of seven streptomycetes isolates were collected from diverse marine samples sourced from Hurghada, Egypt. The isolates were assessed for their capacity to generate bioactive secondary metabolites (SMs) under growing in different media. In addition secondary metabolites produced from the seven isolates were also evaluated for antiviral activity against Cucumber Mosaic Virus (CMV). As a result, the medium No. 5 (Rice medium) was the potent one for production of secondary metabolites. While, the highest isolates can produce secondary metabolites were no St 3 and St 5. Moreover, the activity of CMV for producing local lesions (LLs) Chenopodium amaranticolor L, was significantly inhibited by secondary metabolites produced from St 5(100%), St 3(97.1%); St 4(34.2%); St 7(28.5%), St 6(22.8%), St 2(20%); and St (14.2%) compared with CMV without treatment. In the present study, secondary metabolites produced from marine Streptomycetes (isolates St 3 and St 5) have shown good inhibitory potential against CMV. | ||
| Keywords | ||
| secondary metabolites; production; antiviral; marine; streptomycetes | ||
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