A pharmacological overview on the therapeutic Effects of Cilostazol: Mechanistic Insights | ||
| Archives of Pharmaceutical Sciences Ain Shams University | ||
| Articles in Press, Accepted Manuscript, Available Online from 15 November 2025 | ||
| Document Type: Review Article | ||
| DOI: 10.21608/aps.2025.400288.1239 | ||
| Authors | ||
| Omar Eltoukhy* 1; Ebtehal El-Demerdash Zaki2; Eman Mantawy3; Hend Maghraby4 | ||
| 1Clinical Pharmacy, Faculty of Pharmacy , Misr International University , Cairo , Egypt | ||
| 2Prof and Head of Pharmacology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt | ||
| 3Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University | ||
| 4Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt | ||
| Abstract | ||
| Drug discovery process is a complex and costly process requiring a huge investment of time and money with a high risk of failure. Recently, drug repurposing or repositioning is gaining attention and focus especially with less time needed and known safety profile for the repurposed medication. Researchers keep searching for candidate medications to be repurposed. Cilostazol is a phosphodiesterase III inhibitor used primarily in intermittent claudication. It is readily absorbed from the GIT with 95% of the medication being protein bound and is metabolized in the liver with cytochrome P450. Cilostazol has shown potential for being repurposed owing to its anti-inflammatory, antioxidant and anti-apoptotic effects, in addition to a well-known safety profile and tolerable side effects which are explored and highlighted in this review. Furthermore, this review inspects the preclinical and clinical studies that showed the therapeutic benefits of cilostazol when used as a cardioprotective, hepatoprotective, nephroprotective and neuroprotective. Overall, cilostazol may be a potential candidate medication to be used as an add-on therapy for various conditions owing to its diverse therapeutic actions. | ||
| Keywords | ||
| cilostazol; anti-inflammatory; antioxidant; anti-apoptotic; cardioprotective; hepatoprotective; nephroprotective; neuroprotective | ||
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