The possible ameliorative effects of Basil oil on the colitis induced by Dextran sodium sulfate in Adult Male Albino Rats (Histological , immunohistochemical and scanning electron microscopic studies) | ||
| Benha Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 16 November 2025 PDF (1.59 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2025.415746.2628 | ||
| Authors | ||
| Eman A. Elbanna1; Samar F. Gad2; Essam M. Eid3; Amal S. Elsayed* 4 | ||
| 1Assistant Professor of Anatomy and Embryology, Faculty of Medicine - Benha University | ||
| 2Lecturer of Anatomy and Embryology, Faculty of Medicine - Benha University | ||
| 3Professor of Anatomy and Embryology, Faculty of Medicine - Benha University | ||
| 4M.B.B.Ch., Faculty of medicine, Benha University | ||
| Abstract | ||
| Background: One serious medical condition is ulcerative colitis. Basil is known to have anti-inflammatory effect. Aim: Evaluation of the beneficial effects of basil oil on a rat model of colitis produced by dextran sodium sulfate (DSS). Methods: 40 adult male albino rats were divided into 4 groups randomly. Each group was 10. control group: 10 rats were divided equally into two subgroups: Subgroup Ia: Five rats weren’t given any treatment.Subgroup Ib: Five rats were given corn oil in a dose of 1ml /kg / once daily for 10 days. basil oil-treated group: was given basil oil 0.2% diluted in corn oil as 1ml of the solution /kg/day once daily for 10 days. DSS-treated group: was given DSS 5% in tap water in a 5 mL solution containing 25 mg of DSS / kg /day once daily for 10 days.DSS and basil oil-treated group: was given DSS 5% and basil oil as same dose ,duration of basil oil group and DSS-treated group. Results: : DSS increased disease activity index (DAI). It produced disrupted histological architecture of the colonic mucosa. A statistically significant decrease in PAS reaction was observed, while collagen deposition and iNOS immuno-expression increased when compared to control group. Administration of basil oil with DSS resulted in reduction in DAI, and restoration of colon architecture. the PAS reaction increased, while collagen deposition and iNOS immuno-expression decreased, with no statistical difference with the control group. Conclusion: Basil oil reduced histological alterations in induced ulcerative colitis. | ||
| Keywords | ||
| colitis, basil oil, DSS; anti-inflammatory | ||
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