Liposome-Tagged Salmonella Vnp20009 for Hydroxy Tumor: A Review | ||
| Egyptian Journal of Veterinary Sciences | ||
| Articles in Press, Corrected Proof, Available Online from 16 November 2025 PDF (589.41 K) | ||
| Document Type: Review Artical | ||
| DOI: 10.21608/ejvs.2025.416027.3065 | ||
| Authors | ||
| Saifur Rehman1; Shakeeb Ullah2; IWAN Sahrial Hamid* 3; Mustofa Helmi Effendi4; Hartanto Mulyo Raharjo5; Isa Mahendra6; Suryo Kuncorojakti7; Muhammad Inamullah Malik8; Muhammad Tayyab Khan9; Shahzada khurram Adrian Shah9 | ||
| 1Faculty of Veterinary Sciences, UVAS SWAT KPK, Pakistan | ||
| 2Faculty of Veterinary Sciences UVAS SWAT KPK, Pakistan | ||
| 3Department of Basic Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Kampus C Mulyorejo, Jl. Dr. Ir. H. Soekarno, Surabaya, East Java, 60115, Indonesia | ||
| 4Division of Veterinary Public Health, Faculty of Veterinary Medicine, Universitas Airlangga, Kampus C Mulyorejo, Jl. Dr. Ir. H. Soekarno, Surabaya, East Java, 60115, Indonesia | ||
| 54Division of Veterinary Microbiology, Faculty of Veterinary Medicine, Universitas Airlangga Kampus C Mulyorejo, Jl. Dr. Ir. H. Soekarno, Surabaya, East Java, 60115, Indonesia | ||
| 6Institute of Medicine, University of Tsukuba, Japan | ||
| 76Division of Veterinary Anatomy, Faculty of Veterinary Medicine Universitas Airlangga Kampus C Mulyorejo, Jl. Dr. Ir. H. Soekarno, Surabaya, East Java, 60115, Indonesia | ||
| 8Faculty of Veterinary and Animal Sciences Gomal University Dera Ismail Khan Pakistan | ||
| 9Faculty of Veterinary Sciences The University of Veterinary and Animal Sciences, Swat Pakistan | ||
| Abstract | ||
| Cancer remains an important global health challenge, with traditional treatments such as chemotherapy, radiation, and surgery often limited by their specificity and lack of systemic poisoning. Recent progress in bacterial-mediated cancer therapy, especially using Salmonella Typhimurium strain VNP20009, presents a promising option for select targets and their unique ability to eradicate the tumor, sparing healthy tissue. VNP20009 has been genetically amended to enhance its oncolytic properties and immunogenicity, allowing it to preferably replicate in hypoxic tumor microenvironments. Literature was searched across databases (PubMed, ScienceDirect, Google Scholar, ResearchGate) and Google using keywords with Boolean operators. From 2,825 initial records, 60 articles were screened after duplicate removal. Of these, 40 full texts were assessed, and 27 studies (22 human, 5 animal) met the inclusion criteria for the final review. This review examines the medical capacity of liposome-tag VNP20009 in the treatment of hydroxy tumors, which integrates the drug delivery benefits of liposomes with genetically modified bacterial tumor-targeting capabilities. By encapsulating VNP20009 in biocompatible liposomes, we aim to improve the stability, localization, and release of the therapeutic payload within tumor sites, potentially adapting to the treatment efficacy. We analyze preclinical clinical studies that portray the protection, immunogenicity, and effectiveness of this innovative approach, which describe intensive implications to increase therapeutic results in patients with hydroxy tumors. In addition, our reviews highlight the emerging strategies, such as individual medical and combination treatment, which take advantage of current progress in genomics and immunology with bacterial therapy. We conclude by discussing future research directions that can facilitate the translation of this promising medical strategy from experimental structure to clinical applications, which eventually aims to remove the boundaries of traditional cancer remedies and address the existing health disparities in oncology. | ||
| Keywords | ||
| Bacterial-mediated therapy; Salmonella typhimurium; VNP20009; hydroxy tumors; clinical applications | ||
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