Role of Vitamin C as Protective Antioxidant for Potential Testicular Toxicity Induced by Clozapine Poisoning in Adult Male Albino Rats. | ||
| Egyptian Society of Clinical Toxicology Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 17 November 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/esctj.2025.410774.1096 | ||
| Authors | ||
| Alzahraa Khedr Nassar* 1; Heba Allah Ali Mabrouk2; Aliaa Abd Elhakam Hodeib3; Magdy Mohamed Ashmawy3 | ||
| 1Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, kafrelsheikh University, Egypt. | ||
| 2Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Kafrelsheikh University, Egypt | ||
| 3Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Tanta University, Egypt. | ||
| Abstract | ||
| Background: Atypical antipsychotics as clozapine effectively manage schizophrenia symptoms, while vitamin C supports cellular defense against oxidative stress. Aim of the work: To investigate the impact of clozapine on testicular function in adult male albino rats and evaluate the potential protective effects of vitamin C at both biochemical and histological levels. Material and Methods: This randomized controlled study was conducted on 40 adult male albino rats, which were divided into four equal groups. Group I: Control remained undisturbed in their cages. Group II: Received 1 ml of distilled water orally via a cannula once daily for 28 days. Group III: Administered clozapine at a dose of 20 mg/kg body weight, dissolved in 1 ml of distilled water, orally for 28 days. Group IV: Received the same clozapine treatment as Group III in combination with vitamin C at a dose of 200 mg/kg orally. Results: Follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone levels, hydrogen peroxide concentration, and seminal parameters, significant differences were observed between Group III and Group I, Group III and Group II, Group III and Group IV (P<0.05). Abnormalities were observed in the testicular architecture of Group III compared to Groups I, II, and IV. Group IV exhibited a partial improvement in the testicular histological structure. Conclusion: Oral administration of clozapine daily for 28 days in adult male albino rats caused increase in oxidative stress and reduction in FSH, LH, testosterone levels and parameter of seminal analysis. Vitamin C effectively mitigates these effects, underscoring its potential as a protective agent against clozapine-induced reproductive toxicity. | ||
| Keywords | ||
| Atypical Antipsychotics; Clozapine; Vitamin C, Antioxidant, Testicular Toxicity | ||
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