Exploring Remdesivir Single or Combined: A Mini-Review of Analytical Approaches for Detection and Quantification of the Anti-COVID drug | ||
| Journal of Pharmaceutical Sciences and Drug Manufacturing-Misr University for Science and Technology | ||
| Articles in Press, Accepted Manuscript, Available Online from 18 November 2025 | ||
| Document Type: Review Articles. | ||
| DOI: 10.21608/jpsdm.2025.384407.1032 | ||
| Authors | ||
| Mai H. Abd El-Fattah* 1; Yasmine Ahmed Sharaf2; Heba M El-Sayed2; Said Hassan3 | ||
| 1Pharmaceutical Analytical Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science & Technology, 6th of October City, Giza, 12566, Egypt. | ||
| 2Department of Analytical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt | ||
| 3Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Cairo University | ||
| Abstract | ||
| Background: A comprehensive review of the literature published between 2021 and 2024 in analytical and pharmaceutical chemistry journals has been conducted, focusing on the instrumental methods employed for the determination of Remdesivir (REM). Given its widespread use as an antiviral agent during the COVID-19 pandemic, Remdesivir has been the subject of numerous analytical studies aimed at understanding its pharmacokinetics and ensuring the accuracy of its dosing in various formulations. Aim of Review: The methods reviewed span spectrophotometric, spectrofluorimetric, chromatographic, and electroanalytical techniques, with a particular emphasis on liquid chromatography coupled with UV or mass spectrometric detection, which has become a prominent choice due to its sensitivity and reliability. Concepts of review: These techniques have been applied for the quantification of Remdesivir in bulk drug substances, pharmaceutical formulations, and biological matrices, supporting quality control and therapeutic monitoring. Conclusion: The review critically evaluates the reported methodologies, highlighting advancements in analytical precision and the growing importance of robust, validated techniques for clinical and regulatory purposes. This analysis reflects the evolving role of instrumental techniques in ensuring the safe and effective use of Remdesivir in clinical settings and underscores their relevance beyond the pandemic era. | ||
| Keywords | ||
| Analytical techniques; Antiviral; Covid-19; Remdesivir | ||
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