Multifactorial Assessement of the Antimicrobial, Hematobiochemical, and Anti-Hypercholesterolemic Properties of Oudneya africana Extracts in Rats | ||
| Egyptian Journal of Chemistry | ||
| Articles in Press, Accepted Manuscript, Available Online from 18 November 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2025.426740.12383 | ||
| Authors | ||
| Souad Dali1; Ilhem Ketata Khitouni2; Mohamed Khitouni* 3; Abueliz Modwi4; Adel Kadri5; Azizah Abdulaziz Algreiby3 | ||
| 1Physics and Chemistry Department, Preparatory Institute for Engineering Studies of Gabes, University of Gabes, Tunisia | ||
| 2Faculty of Science of Sfax, Department of Biology, University of Sfax, Tunisia | ||
| 3college of Science, Qassim University | ||
| 4Department of Chemistry, College of Science, Qassim University, Saudi Arabia. | ||
| 5Universite de Sfax, TUNISIA | ||
| Abstract | ||
| Hypercholesterolemia, a pathophysiological metabolic disorder, is major risk factor for cardiovascular diseases, including coronary heart and ischemic heart disease. When accompanied by microbial infections, it can severely compromise immune function, potentially leading to fatal outcomes. The present study evaluates for the first time, the effect of different Oudneya africana (O. africana) extracts on the antimicrobial activity as well as the potential protective effect of the ethanolic extract against hypercholesterolemic Wistar rats. The antimicrobial activity was assessed through disc diffusion and microdilution methods. For the anti-hypercholesterolemic activities, eighteen male Wistar rats (200 to 250 g) were divided into three groups: Group I, control rats with a standard diet. Group II, hypercholesterolemic rats. Group III, hypercholesterolemic rats that were administered O. africana ethanolic extract by gavage at a dose of 250 mg/kg. The hematological and biochemical parameters, as well as the enzymatic antioxidant parameters were investigated. O. africana extracts displayed potent antimicrobial effect. Administration of O. africana ethanolic extract improves the changes in hematological parameters, and significantly (p ≤ 0.05) decreases TC and TG, increases HDL-C, and not affect LDL-C levels. Moreover, O. africana ethanolic extract had significantly higher (p ≤ 0.05), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) towards three organs, and lower thiobarbituric acid reactive substances (TBARS) in kidney and liver tissues, than the control. In conclusion, O. africana plant extracts exhibited antimicrobial potential, and that administration of ethanolic extract induced anti-hypercholesterolemic effect. | ||
| Keywords | ||
| Oudneya africana extracts; antimicrobial; Biochemical; hematological and lipid profile; anti-hypercholesterolemic activity; prediction; pharmacokinetics | ||
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